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NCT04715984 | RECRUITING | Parkinson Disease


Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
Sponsor:

Vanderbilt University Medical Center

Information provided by (Responsible Party):

Sarah Bick

Brief Summary:

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Condition or disease

Parkinson Disease

Intervention/treatment

Neurophysiology recordings

Neural stimulation

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 75 participants
Masking : NONE
Primary Purpose : BASIC_SCIENCE
Official Title : Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment
Actual Study Start Date : 2021-06-02
Estimated Primary Completion Date : 2029-08
Estimated Study Completion Date : 2029-08

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 40 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion criteria
  • * Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
  • * Planned clinical electrode trajectory that contacts caudate
  • * Age greater than or equal to 40
  • * Diagnosis of Parkinson's disease
  • * Able to participate in intraoperative testing
  • * English speaking
  • Exclusion criteria
    • * Age less than 40
    • * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
    • * Movement disorder other than Parkinson's disease

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Location Details

NCT04715984


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Locations


RECRUITING

United States, Tennessee

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37212

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