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NCT04689048 | RECRUITING | Brain Metastases, Adult

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Sponsor:

Baptist Health South Florida

Brief Summary:

The spread of cancer to the brain is referred to as brain metastases. Brain metastases are a common complication of cancer. This study is being done to determine whether the use of a new imaging agent, 18F-fluciclovine, is able to detect which patients are responding to radiation therapy. In addition, this study will look at the changes of the treated brain metastases using this imaging agent over time.

Condition or disease

Brain Metastases, Adult

Brain Metastases

Brain Cancer

Intervention/treatment

18F fluciclovine

Phase

PHASE1

Study Type : INTERVENTIONAL
Estimated Enrollment : 20 participants
Masking : NONE
Primary Purpose : PREVENTION
Official Title : Characterization of Large Brain Metastases With 18F-Fluciclovine PET/CT Treated With Staged Stereotactic Radiosurgery
Actual Study Start Date : 2022-04-04
Estimated Primary Completion Date : 2025-12
Estimated Study Completion Date : 2026-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Male or female, age ≥18 years
  • 2. Performance status, Eastern Cooperative Oncology Group 0-2
  • 3. Confirmed diagnosis of brain metastases with at least one untreated lesion \>2 cm in maximum diameter
  • 4. Plan for SSRS per the treating team
  • 5. For women of childbearing potential, a negative serum pregnancy test within 14 days of registration is required
  • 6. For females of reproductive potential: use of highly effective contraception for at least 4 weeks prior to screening and agreement to use such a method during study participation and for an additional 1 week after post-treatment 18F-fluciclovine positron emission tomography/computerized tomography
Exclusion Criteria
  • 1. Prior anaphylactic reaction to 18F-fluciclovine
  • 2. Evidence of leptomeningeal disease
  • 3. Prior whole-brain radiation therapy
  • 4. Contraindication to MRI (e.g., due to safety reasons, such as presence of a pacemaker)
  • 5. Females pregnant at the expected time of 18F-fluciclovine administration
  • 6. Females who are expecting to be breastfeeding at the time of 18F-fluciclovine and unwilling to stop breast-feeding for 24 hours. Temporary cessation of breastfeeding 24 hours after the time of imaging is allowed
  • 7. Major medical illness or psychiatric/cognitive impairments, which in the investigator's opinion, will prevent completion of protocol therapy and/or preclude informed consent
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Location Details

NCT04689048

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How to Participate

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Locations

RECRUITING

United States, Florida

Miami Cancer Institute

Miami, Florida, United States, 33176