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NCT04535726 | COMPLETED | Heart Failure With Preserved Ejection Fraction

The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity
Sponsor:

Chongqing Medical University

Information provided by (Responsible Party):

dongyingzhang

Brief Summary:

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.

Condition or disease

Heart Failure With Preserved Ejection Fraction

Detailed Description:

Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.

Study Type : OBSERVATIONAL
Estimated Enrollment : 200 participants
Official Title : The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity
Actual Study Start Date : 2020-09-01
Estimated Primary Completion Date : 2022-07-27
Estimated Study Completion Date : 2022-07-27

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Adult aged \>=18years old;
  • * Diagnosed with HFpEF.
  • Diagnostic criteria including
    • 1. left ventricular ejection fraction ≥50%；
    • 2. with the symptoms and/or signs of heart failure；
    • 3. BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
    • 4. at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
    Exclusion Criteria
    • * LVEF less than 45% at any time;
    • * Severe liver failure;
    • * Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease;
    • * Primary pulmonary hypertension;
    • * Severe valvular disease of the left heart;
    • * Chronically bedridden or incapacitated;
    • * Age \<18 years old.
The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity

Location Details

NCT04535726

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How to Participate

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Locations

Not yet recruiting

China,

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China,