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NCT04472338 | RECRUITING | Prostate Carcinoma

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study
Sponsor:

University of Washington

Brief Summary:

This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further understand the genetics of prostate cancer and help identify ways to detect cancer earlier, thereby improving treatment and methods of early detection in the future.

Condition or disease

Prostate Carcinoma

Intervention/treatment

Biospecimen Collection

Laboratory Biomarker Analysis

Quality-of-Life Assessment

Questionnaire Administration

Detailed Description:

OUTLINE: Participants undergo collection of blood, urine, and/or tissue samples every 6-12 months, when any biopsy occurs, and if relevant, at time of curative therapy and 3-9 months after completion of curative therapy for up to 3 years.

Study Type : OBSERVATIONAL
Estimated Enrollment : 450 participants
Official Title : PATROL: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease
Actual Study Start Date : 2020-05-21
Estimated Primary Completion Date : 2030-08-31
Estimated Study Completion Date : 2030-08-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 40 Years
Sexes Eligible for Study: MALE
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * People with prostates ≥40 years of age
  • * Documented germline pathogenic variant in known or suspected genes associated with prostate cancer risk.
Exclusion Criteria
  • * Prior diagnosis of prostate cancer
  • * Medical contraindication to any of the study procedures (e.g., prostate biopsy)
  • * For all cancer types except non-melanoma skin cancer, any cancer treatment with curative intent within the past 12 months (e.g., surgery, radiation, chemotherapy, immunotherapy)
  • * Prior or concurrent participation in an interventional clinical trial aimed at preventing cancer for people with germline variants associated with increased prostate cancer risk
  • * Unable to provide written informed consent
  • * Unable or unwilling to complete clinical care and study procedures as indicated by the study protocol.
Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Location Details

NCT04472338

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

NOT YET RECRUITING

United States, California

City of Hope

Duarte, California, United States, 91010

NOT YET RECRUITING

United States, California

University of California, San Francisco

San Francisco, California, United States, 94143

NOT YET RECRUITING

United States, Illinois

Northwestern

Chicago, Illinois, United States, 60611

NOT YET RECRUITING

United States, Massachusetts

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

RECRUITING

United States, Oregon

OHSU Knight Cancer Institute

Portland, Oregon, United States, 97239

RECRUITING

United States, Pennsylvania

University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, United States, 19104

ACTIVE NOT RECRUITING

United States, Texas

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States, 78229

RECRUITING

United States, Washington

Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, United States, 98109