Consorci Sanitari de Terrassa
Anna Puigdellívol-Sánchez
Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection. Other authors described how none of the elderly patients receiving antihistamines and azythromycin in two nursing homes in Toledo -Spain- during the first wave died or needed hospital admission, even considering that 100% of residents had a positive serological test after that wave. Other authors have described a positive evolution in patients receiving amantadine for their Parkinson's disease. The aim is to evaluate whether the admitted patients who are previously vaccinated or those who were already receiving these treatments showed a better evolution.
COVID19
Influenza Vaccination
ACE Inhibitors
ARB
Antihistamine Allergy
Amantadine
Antihistamine
Amantadine
ACEI
ARB
Influenza vaccine and COVID
The number COVID cases would be related to hospital admissions. Among hospital admissions, the number of previous treatments, the length of admission, the need or not of the Intensive Care Unit (ICU) and their final status (survivors or non survivors) would be studied. If patients that previously received the influenza vaccine or treated with ACEI, ARB, antihistamines or amantadine showed a better evolution, it would be proposed to extend vaccination and the inclusion of ACE inhibitors, ARB, antihistamines or amantadine in the treatment of infection.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 3000 participants |
| Official Title : | Evaluation of Influenza Vaccination and Treatment With ACEI and ARB in the Evolution of SARS-CoV2 Infection |
| Actual Study Start Date : | 2020-03-01 |
| Estimated Primary Completion Date : | 2025-01-19 |
| Estimated Study Completion Date : | 2028-02-24 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
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RECRUITING
Terrassa Hospital
terrace, Barcelona, Spain, 08227