The University of Minnesota
To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
Dupuytren's Disease
Dupuytren Contracture
Dupuytren Disease of Palm and Finger
Dupuytren Disease of Finger
Dupuytrens Contracture of Both Hands
Dupuytren's Disease of Palm of Right Hand
Dupuytren's Disease of Palm of Left Hand
Dupuytren Contracture of Right Palm
Dupuytren Contracture of Left Palm
Dupuytren's Contracture Left
Dupuytren's Contracture Right
Evaluation of Dupuytren's Disease Treatment
This is an observational, pilot study. Participants will be treated according to a standard treatment pathway, which includes contracture release treatment modalities such as limited fasciectomy, PNA and CCH injection, followed by post-operative radiation. All enrolled participants will undergo radiation treatment as soon as possible following contracture release. Radiotherapy will consist of 5 daily treatments of 300 cGy delivered to the palmar area followed by a 6-8 weeks break then a second 5 day course of radiation at 300 cGy, for a total of 3000 cGy in 10 total fractions. This dosing schedule is commonly used in the published literature. The data to be collected about participants, is their Southampton Dupuytren's score, history and clinical symptoms and photographs of their hand. This information will be obtained at baseline (pre-surgical intervention), at radiation treatment planning, approximately 6 weeks after completion of all radiation and at 1 and 2 years following completion of radiotherapy.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 50 participants |
| Official Title : | Efficacy of Post-contracture Release Radiation for the Treatment of Dupuytren's Disease |
| Actual Study Start Date : | 2019-05-31 |
| Estimated Primary Completion Date : | 2026-03-01 |
| Estimated Study Completion Date : | 2026-03-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
The University of Minnesota
Minneapolis, Minnesota, United States, 55455