Brigham and Women's Hospital
Elena Losina
Total knee replacement (TKR) is a common and costly procedure widely used to relieve pain and improve function in patients with symptomatic advanced knee osteoarthritis (OA). As of 2013, the annual incidence of TKR was over 680,000 surgeries and annual costs exceeded $11 billion. Growing evidence suggests that while pain and functional status improve following TKR, physical activity (PA) typically does not surpass pre-TKR levels. Engagement in PA can meaningfully improve quality of life (QoL), pain, and function. Given the large investment in TKR, the effectiveness and cost-effectiveness of TKR could be substantially increased if TKR recipients became more physically active. The Knee Arthroplasty Activity Trial (KArAT) is a randomized controlled trial and participants will be randomly assigned to one of three arms. Participants across all arms will receive usual post-operative care for TKR surgery. Participants in the first arm will complete basic study activities, such as responding to surveys and attending two in-person clinic visits. Participants in the second arm will do the same and also receive a wrist-based physical activity tracker intervention. Participants in the third arm will receive a telephonic active coaching (motivational interviewing) and financial incentives (for reaching physical activity goals) (TAC(MI)+FI) based intervention, as well as a wrist-based physical activity tracker intervention. The second and third arms will be eligible to receive lottery-based financial rewards for wearing a wrist-worn activity tracker for twenty-four months during the study.
Knee Osteoarthritis
Total Knee Replacement
Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives
Wrist based activity tracker wear
Basic Study Activities
NA
The investigators have designed the KArAT trial with two specific aims. First, to conduct a parallel three-arm RCT to establish the efficacy and sustainability of the effect of personalized intervention built on the principles of behavioral science and behavioral economics in improving PA among sedentary people who have undergone TKR. Our second aim is to establish the cost-effectiveness and budget impact of TAC(MI)+FI to improve PA in persons who have undergone TKR. The three arms will include: Arm 1: Usual post-TKR care Arm 2: Usual post-TKR care + Wrist-based physical activity tracker wear Arm 3: Usual post-TKR care + Wrist-based physical activity tracker wear + Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives (TAC(MI)+FI).
Study Type : | INTERVENTIONAL |
Estimated Enrollment : | 600 participants |
Masking : | TRIPLE |
Masking Description : | The investigators, care providers, and outcomes assessors will not be appraised of treatment arm. |
Primary Purpose : | TREATMENT |
Official Title : | Knee Arthroplasty Activity Trial |
Actual Study Start Date : | 2023-04-27 |
Estimated Primary Completion Date : | 2028-06-15 |
Estimated Study Completion Date : | 2028-06-15 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | 40 Years to 85 Years |
Sexes Eligible for Study: | ALL |
Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Northwestern Memorial Hospital
Chicago, Illinois, United States, 60611
RECRUITING
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
RECRUITING
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
RECRUITING
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
RECRUITING
University at Buffalo
Buffalo, New York, United States, 14215