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NCT04093882 | COMPLETED | Blood Brain Barrier

The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease
Sponsor:

Charite University, Berlin, Germany

Information provided by (Responsible Party):

Oliver Peters, MD

Brief Summary:

This study attempts to replicate the findings published in Nature Medicine by Nation and colleagues (2019). By using a large observational cohort (DZNE - Longitudinal Cognitive Impairment and Dementia Study; DELCODE) consisting of cognitively healthy individuals, individuals with subjective cognitive decline, mild cognitive impairment, and dementia due to Alzheimer's disease, an association between the blood-brain barrier and cognitive dysfunction is investigated. The integrity of the blood-brain barrier is investigated by using a novel MRI protocol as well as a novel biomarker in the cerebrospinal fluid.

Condition or disease

Blood Brain Barrier

Alzheimer Disease

Cognitive Dysfunction

Dementia

Intervention/treatment

Contrast agent enhanced MRI using Gadovist

Study Type : OBSERVATIONAL
Estimated Enrollment : 101 participants
Official Title : The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease
Actual Study Start Date : 2019-09-12
Estimated Primary Completion Date : 2021-09-30
Estimated Study Completion Date : 2021-09-30

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 50 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion criteria
  • - ≥ 50 years with neuropsychologically confirmed no cognitive dysfunction, mild cognitive impairment or mild dementia
  • Exclusion cirteria
    • * no current or prior history of any neurological or psychiatric condition, which might affect cognitive function
    • * no neurodegenerative disease other than AD
    • * specifically no extensive vascular white matter dementia or vascular dementia
The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease

Location Details

NCT04093882

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How to Participate

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Locations

Not yet recruiting

Germany,

Charité Universitätsmedizin Berlin

Berlin, Germany, 10117