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NCT03875326 | RECRUITING | Mild Cognitive Impairment

Stimulation to Improve Memory
Sponsor:

University of Michigan

Information provided by (Responsible Party):

Benjamin Hampstead, PhD

Brief Summary:

This study will test the effects of different doses of a form of non-invasive brain stimulation for the treatment of individuals with mild cognitive impairment (MCI) and dementia of the Alzheimer's Type (DAT).

Condition or disease

Mild Cognitive Impairment

Dementia of Alzheimer Type

Intervention/treatment

1 mA HD-tDCS

2 mA HD-tDCS

3 mA HD-tDCS

Sham

Phase

NA

Detailed Description:

This research study is being done to learn important information about the effects of weak electrical stimulation on brain functioning in those with mild cognitive impairment (MCI) and dementia of the Alzheimer's type (DAT). The findings will help determine "how much" stimulation is needed to enhance memory and thinking abilities, how it affects brain functioning, and who is most likely to benefit. Ultimately, this information may guide treatment efforts for those at various stages of Alzheimer's disease. The study will use brain imaging to see whether these treatments change how participants learn and remember information. Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) scans will be used. The study will also use cognitive tests and questionnaires to examine whether participants' memory (and related abilities) change because of treatment. The study will enroll participants with a diagnosis of MCI or DAT. It is expected but not required that participants will be co-enrolled in the University of Michigan Memory and Aging Project (UM-MAP; HUM00000382).

Study Type : INTERVENTIONAL
Estimated Enrollment : 240 participants
Masking : TRIPLE
Primary Purpose : TREATMENT
Official Title : Testing High Definition Transcranial Direct Current Stimulation (HD-tDCS) as Treatment of Mild Cognitive Impairment
Actual Study Start Date : 2019-04-01
Estimated Primary Completion Date : 2025-05-31
Estimated Study Completion Date : 2025-05-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 55 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Diagnosis of Mild Cognitive Impairment (MCI) or dementia of the Alzheimer's type (DAT)
  • 2. Must be MRI compatible, criteria that also apply for High Definition transcranial direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants in the upper body or head)
  • 3. Stable on relevant medications for at least 4 weeks prior to study enrollment
Exclusion Criteria
  • 1. Certain neurological diseases
  • 2. Certain psychiatric conditions
  • 3. Severe sensory impairment
Stimulation to Improve Memory

Location Details

NCT03875326

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Road cancer

University of Michigan

Ann Arbor, Road cancer, United States, 48105