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NCT03831659 | COMPLETED | Migraine


Migraine and Infertility
Sponsor:

Public Assistance - Paris Hospitals

Brief Summary:

The purpose of this study is to determine the prevalence of migraine in infertile women and during in Vitro Fertilization protocol. Migraine is two to three times as common in women as in men. Migraine has considerable impact on quality of life. In Vitro Fertilization has become a common therapeutic modality in modern fertility medicines. Treatment protocols are associated with exaggerated hormonal fluctuations. Estrogen is considered to be closely linked to migraine and its fluctuations have been considered to trigger migrainous headaches.

Condition or disease

Migraine

Intervention/treatment

self-questionnaires

Detailed Description:

In Vitro Fertilization has become a common therapeutic modality in modern fertility medicines. Treatment protocols are associated with exaggerated hormonal fluctuations. Estrogen is considered to be closely linked to migraine and its fluctuations have been considered to trigger migrainous headaches. Both migraine and infertility are associated with impaired quality of life. Objectives: to assess the prevalence of migraine in infertile women and during in Vitro Fertilization protocol in order to improve the management of these patients. Protocol: Women coming to consult at the Port Royal infertility center and meeting the inclusion (infertile women without long-term analgesic treatment) criteria will be offered the study. The information note and no objection form will be given by the gynecologist receiving them for consultation. After collecting their non-opposition, a self-questionnaire will be given to them. This questionnaire is validated in the literature concerning the diagnosis of migraine. It includes questions about medical history and possible headaches. The patient fills it immediately and gives it to the investigator. As part of the usual management, and regardless of their answers to the questionnaire, some of the patients will be reviewed in consultation for the programming of an IVF. During this "incoming" consultation with one of the midwives of the unit, a schedule of migraine headaches will be given to the patients. They will keep it, will complete it in case of migraine, and will give it to the gynecologist during the embryo transfer or the doctor receiving the couple in consultation on day 7 in case of absence of embryo transfer.

Study Type : OBSERVATIONAL
Estimated Enrollment : 137 participants
Official Title : Prevalence of Migraine in Infertile Women and Evolution During in Vitro Fertilization (IVF)
Actual Study Start Date : 2019-03-13
Estimated Primary Completion Date : 2020-03-26
Estimated Study Completion Date : 2020-03-26

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 40 Years
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * infertile women supported in reproductive medical assistance at the Port Royal infertility center
  • * aged between 18 and 40 years old
Exclusion Criteria
  • * long-term analgesic treatment
  • * women under guardianship or curatorship

Migraine and Infertility

Location Details

NCT03831659


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Locations


Not yet recruiting

France,

Hospital Port-Royal

Paris, France, 75014

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