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NCT03829982 | COMPLETED | Diabetes Mellitus, Type 2

The Effects of Light on Glucose Metabolism
Sponsor:

Maastricht University

Brief Summary:

This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.

Condition or disease

Diabetes Mellitus, Type 2

Glucose Intolerance

Prediabetic State

Intervention/treatment

Exposure to bright light during the day

Exposure to dim light during the day

Phase

NA

Detailed Description:

Light has a major influence on the biological clock and several studies suggest that bright light during the day and dim light in the evening are beneficial for the circadian timing system. Nowadays, large parts of the population spend 90% of their time indoors and are thereby exposed to artificial lighting instead of daylight. The artificial light levels are relatively low during the day and continue relatively late in the evening. The lack of a clear natural light-dark cycle could results in delayed timing of the biological clock relative to the behaviour. Optimizing the lighting conditions under controlled laboratory settings might lead to better alignment of the biological clock, which in turn could improve metabolic parameters such as glucose control.

Study Type : INTERVENTIONAL
Estimated Enrollment : 14 participants
Masking : NONE
Primary Purpose : BASIC_SCIENCE
Official Title : The Effects of Light on Glucose Metabolism
Actual Study Start Date : 2018-07-13
Estimated Primary Completion Date : 2020-02-07
Estimated Study Completion Date : 2020-02-07

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 40 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Caucasian
  • * BMI 25-35 kg/m2
  • * Stable weight (+/- 3 kg in the last 3 months)
  • * One of the four criteria for prediabetes
    • * Impaired fasting glucose (6.1 mM to 6.9 mM)
    • * Blood glucose values 7.8 - 11.1 mM 2h after glucose drink consumption during the oral glucose tolerance test (OGTT) in screening
    • * Insulin Resistance: glucose clearance rate ≤ 360 ml/kg/min, as determined using the oral glucose insulin sensitivity (OGIS120) index
    • * HbA1c of 5.7 - 6.4%.
    Exclusion Criteria
    • * Fasting plasma glucose ≥7.0 mM
    • * Blood donation one month prior to study and three months after finishing study.
    • * Participants with extreme chronotypes (going to bed extremely late/early).
The Effects of Light on Glucose Metabolism

Location Details

NCT03829982

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How to Participate

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Locations

Not yet recruiting

Netherlands, Limburg

Maastricht University

Maastricht, Limburg, Netherlands, 6229 is