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NCT03650673 | RECRUITING | Hand Osteoarthritis

A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms
Sponsor:

University Hospital, Montpellier

Brief Summary:

The late-stage forms of degenerative osteoarthritis (OA) are very debilitating and less affordable to therapy. The main objective is to identify early onset symptoms of hand OA patients through imaging techniques (such as ultrasound and MRI). Our primary endpoint is to specify patients with high risk of radiological profression (X-ray).

Condition or disease

Hand Osteoarthritis

Intervention/treatment

Identification of subgroups of patients with early AD with risk of progression

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 150 participants
Masking : NONE
Primary Purpose : HEALTH_SERVICES_RESEARCH
Official Title : A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis
Actual Study Start Date : 2019-07-15
Estimated Primary Completion Date : 2024-07-31
Estimated Study Completion Date : 2024-10-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 60 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • - Early digital osteoarthritis must combine the clinical AND radiological definition.
  • Clinical definition
    • At least one of the following 4 criteria: Pain or stiffness or swelling or deformity of a digital joint (IPP and / or IPD) A breach of at least one PPI and / or IPD Age under 60 at the time of the first symptoms Clinical symptoms have been changing for less than 3 years
    • Radiographic definition
      • The presence of the achievement of at least one PPI and / or IPD. Presence of at least two of the following three criteria: pinching, marginal subchondral condensation, marginal osteophyte Erosion on radiography is not an exclusion criteria
      • - Consent form signed
      • Exclusion criteria
        • * patients suffering from rheumatoid arthritis, rheumatoid psoriasis or any other inflammatory rheumatism
        • * patients suffering from metabolic diseasis such as gout, hemochromatosis, Wilson's disease; or from congenital disease such as displasie, osteogenesis,
        • * Presence of advanced radiographic osteoarthritis based in Kellgreen Lawrence score (=4) in one joint among the 10 previous sites.
        • * Not able to provide a sample of blood for any reasons
        • * MRI contraindication
        • * Being in exclusion period determined by another previous study
        • * Subject non affiliated to social insurance
        • * Pregnant or lactating women
        • * Vulnerable people based in L1121-5 article of CSP
        • * Elderly subject or protected subjects disabled to give their consent
        • * Subjects private of freedom by court or administrative order
A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms

Location Details

NCT03650673

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

France,

Department of Rheumatology, CHU Montpellier

Montpellier, France, 34295