University of Alabama at Birmingham
Jonathan E McConathy
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer \[C-11\]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with \[C-11\]PiB-PET, and cognitive status will be the primary outcome of this imaging study.
Alzheimer Disease
[C-11]PiB-PET/MRI
PHASE2
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer \[C-11\]PiB in participants in the UAB-ADC cohort. The amount and distribution of \[C-11\]PiB in the brain will be correlated to demographic, clinical, genetic, and biospecimen data acquired through the separate ongoing UAB-ADC study. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with \[C-11\]PiB-PET, and cognitive status will be the primary outcome of this imaging study. As a secondary aim, the investigators will assess the ability of the early flow frames from \[C-11\]PiB-PET and brain volumetric measurements with MRI to serve as a marker of neuronal injury and to predict cognitive status in conjunction with the amyloid-PET results.
Study Type : | INTERVENTIONAL |
Estimated Enrollment : | 160 participants |
Masking : | NONE |
Primary Purpose : | DIAGNOSTIC |
Official Title : | UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy |
Actual Study Start Date : | 2018-04-20 |
Estimated Primary Completion Date : | 2026-04-01 |
Estimated Study Completion Date : | 2026-04-01 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | 50 Years |
Sexes Eligible for Study: | ALL |
Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
University of Alabama at Birmingham Medical Center
Birmingham, Alabama, United States, 35294