Masonic Cancer Center, University of Minnesota
This is a Phase II study of allogeneic hematopoietic stem cell transplant (HCT) using a myeloablative preparative regimen (of either total body irradiation (TBI); or, fludarabine/busulfan for patients unable to receive further radiation). followed by a post-transplant graft-versus-host disease (GVHD) prophylaxis regimen of post-transplant cyclophosphamide (PTCy), tacrolimus (Tac), and mycophenolate mofetil (MMF).
Acute Leukemia
Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Lymphoma
Chronic Myelogenous Leukemia
Plasma Cell Leukemia
Myeloproliferative Neoplasms
Myelofibrosis
Myelodysplasia
Refractory Anemia
High Risk Anemia
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Marginal Zone B-Cell Lymphoma
Follicular Lymphoma
Lymphoplasmacytic Lymphoma
Mantle-Cell Lymphoma
Prolymphocytic Leukemia
Diffuse Large Cell Non Hodgkins Lymphoma
Lymphoblastic Lymphoma
Burkitt Lymphoma
High Grade Non-Hodgkin's Lymphoma, Adult
Multiple Myeloma
Juvenile Myelomonocytic Leukemia
Biphenotypic/Undifferentiated/Prolymphocytic Leukemias
MRD Positive Leukemia
Natural Killer Cell Malignancies
Acquired Bone Marrow Failure Syndromes
HSCT with TBI Regimen
HSCT with Non-TBI Regimen
PHASE2
Study Type : | INTERVENTIONAL |
Estimated Enrollment : | 300 participants |
Masking : | NONE |
Primary Purpose : | TREATMENT |
Official Title : | Myeloablative Allogeneic Hematopoietic Cell Transplantation Using a Related or Unrelated Donor for the Treatment of Hematological Diseases |
Actual Study Start Date : | 2018-03-30 |
Estimated Primary Completion Date : | 2026-06-10 |
Estimated Study Completion Date : | 2027-06-10 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | to 60 Years |
Sexes Eligible for Study: | ALL |
Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Masonic Cancer Center at University of Minnesota
Minneapolis, Minnesota, United States, 55337