Thinking of joining a study?

Register your interest

Become a volunteer?

NCT03300726 | COMPLETED | Alzheimer Disease, Late Onset

Synaptic Injury and Functional Connectivity in Alzheimer's Disease
Sponsor:

Ohio State University

Information provided by (Responsible Party):

Rawan Tarawneh

Brief Summary:

The purpose of this study is to examine cross-sectional associations between CSF markers of synaptic injury (Ng and SNAP-25) and functional connectivity in default and semantic memory networks using 3T- fMRI in individuals with MCI (i.e. the earliest clinically detectable stage of cognitive impairment) due to AD or mild AD dementia (CDR 0.5-1; n=20) and cognitively normal controls (CDR 0; n=20).

Condition or disease

Alzheimer Disease, Late Onset

Intervention/treatment

CSF analysis

Functional MRI

Detailed Description:

SPECIFIC AIMS: Aim 1: Investigate correlations between CSF biomarkers of synaptic injury (Ng and SNAP-25) and functional connectivity (FC) within the default mode network (DMN) using resting-state fMRI (adjusting for age, gender, apolipoprotein-E4 \[APOE4\] genotype, task performance, and regional brain atrophy) in MCI/AD and controls. Aim 2: Examine correlations between CSF biomarkers of synaptic injury and functional connectivity (FC) within the semantic memory network on task-activated fMRI using the Famous Name Discrimination Task (FNDT) (adjusting for age, gender, APOE4 genotype, task performance, and regional brain atrophy) in MCI/AD and controls.

Study Type : OBSERVATIONAL
Estimated Enrollment : 35 participants
Official Title : Cerebrospinal Fluid Markers of Synaptic Injury and Functional Connectivity in Alzheimer's Disease
Actual Study Start Date : 2018-02-12
Estimated Primary Completion Date : 2021-09-22
Estimated Study Completion Date : 2021-09-22

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 60 Years to 95 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria: Participants included in the study should meet all 4 inclusion criteria
  • 1. 60 years of age or older
  • 2. A clinical diagnosis of MCI, mild AD dementia, or normal cognition
  • 3. No significant medical or surgical co-morbidities
  • 4. No contraindications to LP or MRI.
  • Exclusion criteria: Participants with any of the following criteria will be excluded from the study
    • 1. Participants with MCI due to AD or mild AD dementia who have been treated with cholinesterase inhibitors or glutamate antagonists in the 3 months prior to study enrollment
    • 2. Individuals with any past history of ischemic or traumatic brain injury
    • 3. Individuals with imaging evidence of significant cerebrovascular disease or structural brain lesions (e.g. tumor, demyelinating disorders, infection, or congenital anomalies)
    • 4. Active mood disorder
    • 5. Active alcohol use
    • 6. Active use of benzodiazepines, barbiturates, anticholinergic, or anti-epileptic medications
Synaptic Injury and Functional Connectivity in Alzheimer's Disease

Location Details

NCT03300726

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Ohio

The Ohio State University Wexner Medical Center

Columbus, Ohio, United States, 43210