McMaster University
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.
Prostate Cancer
Cardiovascular Disease
Nutrition
Exercise
Smoking cessation
Statin (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)
ACE inhibitor
NA
RADICAL PC describes two prospective studies, one of which is embedded in the other. RADICAL PC1 is a prospective cohort study of men within one year of their first diagnosis of prostate cancer, or treated with Androgen Deprivation Therapy for the first time within 6 months prior to enrollment visit, or to be treated with Androgen Deprivation Therapy for the first time within one month after the enrollment visit. Its goal will be to identify factors associated with the development of cardiovascular disease among men with prostate cancer, with a particular focus on Androgen Deprivation Therapy. RADICAL PC2 is a randomized, controlled trial embedded in RADICAL PC1. RADICAL PC2 will test a systematic approach to modifying cardiovascular and lifestyle risk factors in men within one year of their first diagnosis of prostate cancer, or treated with Androgen Deprivation Therapy for the first time within 6 months prior to enrollment visit, or to be treated with Androgen Deprivation Therapy for the first time within one month after the enrollment visit.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 6000 participants |
| Masking : | NONE |
| Primary Purpose : | TREATMENT |
| Official Title : | The Role of Androgen Deprivation Therapy in Cardiovascular Disease - a Longitudinal Prostate Cancer Study (RADICAL PC1) & a RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (RADICAL PC2) |
| Actual Study Start Date : | 2015-10-21 |
| Estimated Primary Completion Date : | 2026-12 |
| Estimated Study Completion Date : | 2026-12 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 45 Years |
| Sexes Eligible for Study: | MALE |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Georgia Cancer Center at Augusta University
Augusta, Georgia, United States, 30912
RECRUITING
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
RECRUITING
Westmead Hospital
Westmead, New South Wales, Australia, 2145
RECRUITING
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
RECRUITING
Flinders Medical Center
Adelaide, South Australia, Australia, 5042
RECRUITING
Clinical Research Center of Brazil
Brasilia, DF, Brazil, 71625175
RECRUITING
Felício Rocho Hospital
Belo Horizonte, Minas Gerais, Brazil, 30110-934
RECRUITING
Federal University of Triangulo Mineiro
Uberaba, Minas Gerais, Brazil, 38025-260
RECRUITING
Angelina Caron Hospital Society
Campina Grande do Sul, Paraná, Brazil, 83.430-000
RECRUITING
Clinical Research Nucleus Hospital do Rocio
Long field, Paraná, Brazil,
RECRUITING
Medical Center São Francisco
Curitiba, Paraná, Brazil, 80810-050
RECRUITING
Institute of Integral Medicine Fernando Figueira - Imip
Recife, Pernambuco, Brazil, 50.070-902
RECRUITING
Ijuí Charity Hospital
Ijuí, Rio Grande do Sul, Brazil, 98700-000
RECRUITING
Porto Alegre Clinic Hospital
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
RECRUITING
Brotherhood of the Holy House of Mercy of Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90050-170
RECRUITING
MAE OF GOD HOSPITAL
Porto Alegre, Rio Grande do Sul, Brazil, 90840-440
RECRUITING
Barueri Municipal Hospital
Barueri, São Paulo, Brazil, 06463-320
RECRUITING
Faculty of Medicine, Paulista State University - Botucatu Campus - UNESP
Bottled, São Paulo, Brazil, 18618-687
RECRUITING
São Francisco University Hospital in the Providence of God
Bragança Paulista, São Paulo, Brazil, 12.916-542
RECRUITING
Foundation Doctor Amaral Carvalho
Jaú, São Paulo, Brazil, 17210080
RECRUITING
Regional College of Medicine Foundation of São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil, 15090-000
RECRUITING
Integral Research and Teaching
Votuporanga, São Paulo, Brazil, 15501-405
RECRUITING
National Institute of Cardiology
Rio de Janeiro, Brazil, 22240-006
RECRUITING
Santa Casa de São Paulo (Ipitec)
São Paulo, Brazil, 01223-001
RECRUITING
Hospital Germany Oswaldo Cruz
São Paulo, Brazil, 01327001
RECRUITING
Japanese-Brazilian Beneficence of São Paulo. Nipo-Brazilian Hospital
São Paulo, Brazil, 02189-000
RECRUITING
Marina Leonardo
São Paulo, Brazil, 04014-002
RECRUITING
Heart Institute of the Hospital das Clínicas, Faculty of Medicine, University of São Paulo and Zerbini Foundation (Incor)
São Paulo, Brazil, 05403-000
RECRUITING
Santa Marcelina Hospital
São Paulo, Brazil, 08270-120
RECRUITING
D'Or Institute for Research and Teaching
São Paulo, Brazil, 4543000
RECRUITING
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
RECRUITING
St. Joseph's Healthcare
Hamilton, Ontario, Canada, Litten 4 AT
RECRUITING
Juravinski Cancer Centre
Hamilton, Ontario, Canada, To add 1 s.
RECRUITING
Queen's University
Kingston, Ontario, Canada, Great eyeliner
RECRUITING
Grand River Hospital, Grand River Regional Cancer Centre
Kitchener, Ontario, Canada, N2G 1G3
RECRUITING
London Health Sciences Centre
London, Ontario, Canada, Wicker
RECRUITING
London Health Sciences, Victoria Hospital
London, Ontario, Canada, Wicker
RECRUITING
Niagara Health, St. Catharines Site
Niagara, Ontario, Canada, L2S 0A9
RECRUITING
Ottawa Hospital Research Institute
Ottawa, Ontario, Canada, K1h 8l6
RECRUITING
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
ACTIVE NOT RECRUITING
University Health Network, Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2C1
RECRUITING
University Hospital of Montreal
Montreal, Quebec, Canada, H2X 0A9
RECRUITING
Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
RECRUITING
Hospital Maisonneuve-Rosemont
Montréal, Quebec, Canada, H1T 2M4
RECRUITING
McGill University
Montréal, Quebec, Canada, H3A 0g4
RECRUITING
Laval University
Quebec City, Quebec, Canada, G1V 0A6
RECRUITING
Sherbrooke University Center
Sherbrooke, Quebec, Canada, J1H 5N4
NOT YET RECRUITING
San Ignacio University Hospital
Bogota, Cundinamarca, Colombia,
RECRUITING
FOSCAL
Floridablanca, Santander, Colombia,
RECRUITING
Foundation Valley of Lili
Cali, Valle del Cauca, Colombia,
RECRUITING
Heart Institute - Holon Medical Center
Colon, Israel, 5840608
RECRUITING
Rabin Medical Center
Petach Pumpkin, Israel, 4941492
RECRUITING
Tel-Aviv Sourasky Medical Centre
Tel Aviv, Israel, 6423906
TERMINATED
Istanbul University
Istanbul, Turkey,