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NCT03039439 | RECRUITING | Parathyroid Gland Adenoma

Molecular and Immunohistochemical Profiling of Tumors in Patients with Parathyroid Tumors
Sponsor:

M.D. Anderson Cancer Center

Brief Summary:

This trial studies molecular and immunohistochemical profiling of tumors in patients with parathyroid tumors. Studying molecular and immunohistochemical profiling of tumors may help doctors avoid inconsistencies in diagnosis, unnecessary or incomplete surgery, surgical morbidity, psychological stress, and inadequate follow up.

Condition or disease

Parathyroid Gland Adenoma

Parathyroid Gland Atypical Adenoma

Parathyroid Gland Carcinoma

Primary Hyperparathyroidism

Intervention/treatment

Biospecimen Collection

Laboratory Biomarker Analysis

Detailed Description:

PRIMARY OBJECTIVES: I. To determine the differences in clinical behavior and immunohistochemical (IHC) biomarkers between parathyroid carcinoma (PC), atypical neoplasm (AN) and parathyroid adenoma (PA). II. To determine which potential genes can be used in patients with parathyroid tumors for diagnostic purposes. OUTLINE: Previously collected tumor tissue and blood samples are analyzed via immunohistochemical profiling for identifying potential genes showing molecular aberrations as other types of cancer.

Study Type : OBSERVATIONAL
Estimated Enrollment : 310 participants
Official Title : Molecular and Immunohistochemical Profiling of Tumor from Patients with Parathyroid Tumors for Evaluation of Targeted Agents
Actual Study Start Date : 2015-11-24
Estimated Primary Completion Date : 2028-11-30
Estimated Study Completion Date : 2028-11-30

Information not available for Arms and Intervention/treatment

Ages Eligible for Study:
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * The patient cohort for this study consists of all patients within the prospectively maintained parathyroid database within the Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center (MDACC) or from collaborating sites, with tissue or blood available from 1968-2015, previously consented for the use of the tissue for research purposes (via Protocols LAB 08-0034, PA11-0695 and LAB03-0320 or the appropriate external mechanism for collaborating sites).
  • * All patients with a known diagnoses of primary hyperparathyroidism (PHPT) operated/treated in the Department of Surgical Oncology of MDACC or at a collaborating site. Patients that have provided consent for the use of the tissue or blood for research purposes will then be considered for our study (via Protocol LAB03-0320 and LAB 08-0034 or the appropriate external mechanism for collaborating sites).
  • * All consented patients with known diagnoses of PHPT with a histopathological diagnosis of: parathyroid carcinoma, atypical parathyroid neoplasm or parathyroid adenoma. There will be no restrictions on age, gender, or ethnicity.
  • * Selected patients obtained through outside collaboration who meet the selection criteria for tissue availability and diagnostic suitability for inclusion in the study.
Exclusion Criteria
  • * Patients without tissue available for analysis.
Molecular and Immunohistochemical Profiling of Tumors in Patients with Parathyroid Tumors

Location Details

NCT03039439

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Texas

M D Anderson Cancer Center

Houston, Texas, United States, 77030