Children's Hospital Medical Center, Cincinnati
The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study. The study will also use blood (serum and plasma) and tissue collected and stored in a tissue bank maintained by the Department of Hematology/Oncology.
Vascular Anomaly
Generalized Lymphatic Anomaly
Kaposiform Hemangioendothelioma
Kaposiform Lymphangiomatosis
Gorham-Stout Disease
Klippel Trenaunay syndrome
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal Nevi
While vascular anomalies are rare diseases, they can be life-threatening and devastating to affected children and their families. Advances in diagnosis, monitoring and therapies will be significantly improved if non-invasive biomarkers that are sensitive and specific can be identified. Obtaining a tissue biopsy to help in diagnosis can actually worsen the disease and so identification of specific blood biomarkers is highly desirable. Studies will measure angiogenic factors in serum and plasma samples at baseline and on therapy. Tissue removed during surgical resection or blood removed prior to sclerotherapy will be used to obtain cells and tissue for the assessment of where biomarkers are coming from and to identify disease-causing pathways for new therapeutic targeting.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 1000 participants |
| Official Title : | Identification of Biomarkers for Patients with Vascular Anomalies |
| Actual Study Start Date : | 2015-04 |
| Estimated Primary Completion Date : | 2050-12 |
| Estimated Study Completion Date : | 2050-12 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 1 Day |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
TERMINATED
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
RECRUITING
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229