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NCT02763683 | RECRUITING | Parkinsons

Investigations of Dementia in Parkinson Disease
Sponsor:

Washington University School of Medicine

Brief Summary:

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Condition or disease

Parkinson's

Intervention/treatment

PiB and VAT

Detailed Description:

The purpose of this study is to use a brain imaging method called PIB PET and VAT PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. The investigators will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.

Study Type : OBSERVATIONAL
Estimated Enrollment : 320 participants
Official Title : Investigations of Dementia in Parkinson Disease
Actual Study Start Date : 2016-06
Estimated Primary Completion Date : 2030-03
Estimated Study Completion Date : 2030-03

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 50 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.
Exclusion Criteria
  • * history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.
  • * severe systemic diseases.
  • * inability to lie still for 90 minutes.
  • * metallic implants, pacemakers, or any other contraindication to MRI.
  • * refusal to consent to brain donation.
Investigations of Dementia in Parkinson Disease

Location Details

NCT02763683

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How to Participate

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Locations

RECRUITING

United States, Missouri

Washington University in St. Louis

St Louis, Missouri, United States, 63110