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NCT02087865 | COMPLETED | Genetic Risk for Alzheimer's Disease

Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease
Sponsor:

The Cleveland Clinic

Information provided by (Responsible Party):

Stephen Rao

Brief Summary:

This study examines the sensitivity of functional MRI to detect brain changes caused by donepezil HCL (a cholinesterase inhibitor) in healthy older adults at genetic risk for Alzheimer's Disease.

Condition or disease

Genetic Risk for Alzheimer's Disease

Intervention/treatment

donepezil HCL

Placebo

Phase

PHASE4

Detailed Description:

This 24-week study will examine the sensitivity of functional MRI to detect brain changes caused by donepezil HCL (a cholinesterase inhibitor) in healthy older adults at genetic risk for Alzheimer's Disease. Participants with a family history of Alzheimer's Disease will be eligible for this study. Participants without a family history of AD will also be enrolled to serve as a control group.

Study Type : INTERVENTIONAL
Estimated Enrollment : 89 participants
Masking : TRIPLE
Primary Purpose : OTHER
Official Title : Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease
Actual Study Start Date : 2014-05
Estimated Primary Completion Date : 2021-12-20
Estimated Study Completion Date : 2021-12-20

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 60 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Normal general cognitive function
  • * High Risk Group Only: Family history (1st degree relative) of AD
  • * Low Risk Group Only: No family history (1st or 2nd degree relative) of AD
  • * Visual and auditory acuity adequate for neuropsychological testing
Exclusion Criteria
  • * Current or past history of
  • * neurological illnesses/conditions
  • * head trauma with significant loss of consciousness
  • * medical illnesses/conditions that may affect brain function
  • * severe psychiatric disorder
  • * substance abuse
  • * unstable or severe cardiovascular disease or asthmatic condition
  • * history of stroke or transient ischemic attack
Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease

Location Details

NCT02087865

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Ohio

Cleveland Clinic Center for Brain Health

Cleveland, Ohio, United States, 44195