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NCT01580982 | RECRUITING | Lung Neoplasms

Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer
Sponsor:

University of Colorado, Denver

Brief Summary:

The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.

Condition or disease

Lung Neoplasms

Detailed Description:

To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers. To estimate the proportion of patients that subsequent therapy is altered based on the information acquired from such biopsies.

Study Type : OBSERVATIONAL
Estimated Enrollment : 175 participants
Official Title : Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers
Actual Study Start Date : 2012-01-23
Estimated Primary Completion Date : 2026-01-01
Estimated Study Completion Date : 2027-01-30

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 85 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies
  • 2. Aged 18 years or older
  • 3. Either a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis.
  • 4. Patients must have the ability to understand and willingness to sign an informed consent document.
Exclusion Criteria
  • -
Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer

Location Details

NCT01580982

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How to Participate

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Locations

RECRUITING

United States, Colorado

University of Colorado Cancer Center

Aurora, Colorado, United States, 80045