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NCT00512343 | Recruiting | Arthritis


Synovial Fluid Bank From Arthritic Patients
Sponsor:

Gilles Boire

Information provided by (Responsible Party):

Gilles Boire

Brief Summary:

The objectives of this group project is to collect synovial fluid (SF) and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels.

Condition or disease

Arthritis

Detailed Description:

Our group has developed interdisciplinary expertise in biomarkers related to distinct aspects of inflammation-induced joint damage, most notably those associated with degradation of components of the extracellular matrix, bone loss, or associated with post-translational changes on protease inhibitors. The objectives of this group project is to collect SF and paired sera and carry out preclinical studies to evaluate, alone or by combination testings, the potential of novel biomarkers for their prevalence and diagnostic/prognostic values in patients with arthritis, and to determine how therapeutic intervention regulate their levels. More specifically, we will study (1) biomarkers associated with osteoclastic bone resorption and synthesis/degradation of cartilage, (2) inhibitors of enzymes (calpastatin) that are preferentially targeted by rheumatoid patients, as well as (3) enzymes (e.g. Matrix Metalloproteinases (MMPs)) responsible for the cleavage of components of the articular cartilage. Finally, we propose to characterize the repertoire of specific active proteases in the SF of arthritic patients concomitantly to the use biomarkers (neoepitopes of cleaved collagens) previously associated with cartilage destruction and synthesis to identify new targets for the development of protease inhibitors for the treatment of arthritis. Furthermore, our project will also provide the opportunity to test the potential of measuring the net proteolytic activity by Fluorescent-Activated Substrate Conversion as a method of monitoring disease activity and treatment efficiency in a clinical setting.

Study Type : Observational
Estimated Enrollment : 500 participants
Official Title: Establishment of a Bank of Synovial Fluids and Paired Sera From Arthritic Patients for the Evaluation of New Methods Facilitating the Diagnosis and the Monitoring of Progression and Therapy of Arthritis.
Actual Study Start Date : June 2002
Estimated Primary Completion Date : December 2025
Estimated Study Completion Date : September 2030

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 3 Years to 95 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Significant joint effusion
Exclusion Criteria
  • Hemorrhagic effusion
  • Traumatic effusion
  • Less than 3 ml total of collected fluid (used for routine analysis and culture)
  • Inability or refusal to consent

Synovial Fluid Bank From Arthritic Patients

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Synovial Fluid Bank From Arthritic Patients

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Locations


Recruiting

Canada, Quebec

Centre hospitalier universitaire de Sherbrooke

Sherbrooke, Quebec, Canada, J1H 5N4

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