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NCT06700720 | NOT YET RECRUITING | Coronary Artery Disease

YN001-004 in Patients With Coronary Atherosclerosis in Australia
Sponsor:

Beijing Inno Medicine Co., Ltd.

Brief Summary:

This study is to evaluate the efficacy and safety of intravenously administered YN001 in patients with coronary atherosclerosis in Australia. This study will be conducted in eligible participants with a diagnosis of coronary atherosclerosis, and at least 1 coronary artery is blocked determined by coronary computed tomography angiography (CCTA)

Condition or disease

Coronary Artery Disease

Coronary Atherosclerotic Disease

Intervention/treatment

Dose 1 YN001

Dose 2 YN001

Evolocumab

Phase

PHASE2

Detailed Description:

This is a multicenter, randomized, open label, parallel-group, proof of concept study. It is designed to determine if the study drug, called YN001, administered in addition to evolocumab can effectively reduce the total amount of plaque formed in the coronary artery as measured by CCTA from baseline to week 13. A total of 12 patients with coronary atherosclerosis are expected to be enrolled and will be randomly assigned in a 1:1 ratio to 1 of 2 YN001 treatment arms (6 patients per arm) with 2 different dose levels for 12 weeks. The study will be comprised of a maximum 41-day screening period (Day -42-Day -2), a baseline period (Day-1), a treatment and observation period (W1D1- W13D7), and a safety follow-up period (14 days post last dose).

Study Type : INTERVENTIONAL
Estimated Enrollment : 12 participants
Masking : SINGLE
Primary Purpose : TREATMENT
Official Title : A Phase Ⅱa Clinical Study to Evaluate the Efficacy and Safety of YN001 in Patients With Coronary Atherosclerosis in Australia
Actual Study Start Date : 2024-12-16
Estimated Primary Completion Date : 2025-09-11
Estimated Study Completion Date : 2025-09-11

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Fully understand the purposes, features, and methods of the study, and sign the ICF before performing any assessment.
  • 2. Male or female Australia patients between 18 and 75 years.
  • 3. Patients diagnosed with coronary atherosclerosis, and at least 1 vessel with diameter stenosis determined by coronary computed tomography angiography (CTA).
  • 4. Female patients must be non-pregnant and non-lactating, and females of childbearing potential (including a female partner of a male patient) must agree to use 1 effective contraception method from the screening period to 3 months after receiving their last dose of the study drug. In addition, male patients must be willing to refrain from sperm donation during this time.
  • 5. Willing and able to comply with the requirements of protocol to the best of the patient's and investigator's knowledge.
Exclusion Criteria
  • 1. Prior treatment with other investigational drug(s) within 30 days or 5 half-lives, whichever is longer, prior to randomization.
  • 2. Previously received YN001.
  • 3. Any type of vaccination within 4 weeks prior to randomization.
  • 4. Contraindication for coronary CTA (e.g., known history of anaphylactic contrast reactions).
  • 5. Severe coronary calcification.
  • 6. Multi-vessel severe disease.
  • 7. Recent acute ST-segment elevation myocardial infarction (STEMI) occurred within 2 weeks prior to randomization.
  • 8. Relapse and highly symptomatic arrhythmia uncontrolled by drugs within the past 3 months, such as ventricular tachycardia, atrial fibrillation with rapid ventricular rate and paroxysmal supraventricular tachycardia.
  • 9. Prior treatment with CABG, heart transplantation, SAVR/TAVR, etc., or CABG, heart transplantation, SAVR/TAVR, etc., is required or planned during the study.
  • 10. PCI performed within 4 weeks prior to randomization or PCI is required or planned during study treatment.
  • 11. New York Heart Association (NYHA) class III or IV, or last known left ventricular ejection fraction (LVEF) \<40%.
  • 12. Recent clinically evident stroke occurred within 6 months prior to randomization (except for TIA).
  • 13. Evidence of major diseases that not recovered within 2 weeks prior to randomization, or major surgery is expected during the study.
  • 14. Presenting with history of malignancy (except in patients who have been disease-free \>5 years; or whose only malignancy has been basal or squamous cell skin carcinoma).
  • 15. Systolic blood pressure of ≥150 mmHg at final screening despite antihypertensive therapy.
  • 16. Active liver disease or hepatic dysfunction defined by any of ALT, AST, or total bilirubin \> 2 times upper limit of normal (ULN) at final screening.
  • 17. Presence of renal insufficiency.
  • 18. Poorly controlled (defined by HbA1c \> 9%) type 2 diabetes mellitus.
  • 19. A positive hepatitis B surface antigen (HBsAg), or positive antibody against hepatitis C virus (anti-HCV) or human immunodeficiency virus (anti-HIV), or positive treponema pallidum antibody (TP-Ab).
  • 20. Presence of any other diseases or conditions (apart from those outlined above) that, in the opinion of the investigator, would make it unsuitable for the patient to participate in this study.
YN001-004 in Patients With Coronary Atherosclerosis in Australia

Location Details

NCT06700720

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

Australia, Australian Capital Territory

Canberra Hospital

Canberra, Australian Capital Territory, Australia,

Not yet recruiting

Australia, Queesland

Core Research Group Pty Ltd

Milton, Queesland, Australia,