AbbVie
A migraine attack is a moderate or severe headache that usually occurs on one side of the head and is often accompanied by throbbing, sensitivity to light, sensitivity to sound, nausea, or other symptoms. The main goal of the study is to see if atogepant is effective, safe, and well-tolerated in treating migraine attacks quickly. Atogepant is a medicine currently approved for the preventive treatment of migraine in adults and has been shown to be effective and well tolerated when taken daily to prevent migraine attacks. This study includes double-blind phase means that neither the participants nor the study doctors know who is given which study treatment (atogepant or placebo) followed by an open-label phase meaning that both participants and study doctors know which study treatment is given. All participants will receive atogepant during the open-label part of the study. This study will include 1300 participants aged 18-75 years with a history of migraine at approximately 160 sites across the world. All participants will receive both atogepant and placebo to treat qualifying migraines. At the start of the study, participants will be randomized to 1 of 4 dosing sequences to determine when they will receive atogepant and when they will receive placebo during the study. After treating 4 qualifying migraine attacks, participants will receive open-label atogepant for any additional migraine attacks they have until the end of the study (Week 24). There may be a bigger responsibility for participants in this study than there would be in participants receiving standard of care treatment. participants will attend regular visits during the study at a hospital or clinic, as well as telephone visits, and the effects of treatment will be checked by completion of questionnaires in an electronic diary, medical assessments, blood tests, and checking for side effects.
Migraine
Atogepant
Placebo for Atogepant
PHASE3
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 1300 participants |
| Masking : | QUADRUPLE |
| Primary Purpose : | TREATMENT |
| Official Title : | Randomized, Double-blind, Placebo-Controlled, Multiple-Attack Study With an Open-Label Extension to Evaluate the Efficacy, Safety, Tolerability, and the Consistency of Effect of Atogepant for the Acute Treatment of Migraine (ECLIPSE) |
| Actual Study Start Date : | 2024-03-25 |
| Estimated Primary Completion Date : | 2025-07-07 |
| Estimated Study Completion Date : | 2026-11 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years to 75 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Antwerp University Hospital /ID# 257582
Edegem, Antwerp, Belgium, 2650
RECRUITING
University Hospital Brussels /ID# 257584
Throw, Brussels Capital, Belgium, 1090
RECRUITING
Jessa Hospital /ID# 257578
Hasselt, Limburg, Belgium, 3500
RECRUITING
Ezz Sintja Tower/If# 257585
Used, West Flanders, Belgium, 8000
RECRUITING
AZ Groeninge /ID# 257586
Kortrijk, Belgium, 8500
RECRUITING
H.-Hartziekenhuis Lier /ID# 257577
Lier, Belgium, 2500
RECRUITING
CHR de la Citadelle /ID# 257587
Liège, Belgium, 4000
RECRUITING
Cabinet Prive Dr Sava /ID# 257581
Saint Nicholas, Belgium, 4420
ACTIVE NOT RECRUITING
The first affiliated hospital of bengbu medical college /ID# 258758
Bengbu, Anhui, China, 233004
COMPLETED
Beijing Friendship Hospital /ID# 258830
Beijing, Beijing Municipality, China, 100032
ACTIVE NOT RECRUITING
Xuanwu Hospital Capital Medical University /ID# 258510
Beijing, Beijing Municipality, China, 100053
ACTIVE NOT RECRUITING
Peking University Third Hospital /ID# 259573
Beijing, Beijing Municipality, China, 100191
ACTIVE NOT RECRUITING
Chinese PLA General Hospital /ID# 257540
Beijing, Beijing Municipality, China, 100853
ACTIVE NOT RECRUITING
Peking University First Hospital /ID# 258672
ξ成district, Beijing Municipality, China, 100034
COMPLETED
Fujian Medical University Union Hospital /ID# 259575
F U axis, Fujian, China, 350001
ACTIVE NOT RECRUITING
The First Affiliated Hospital of Xiamen University /ID# 259576
Xiamen, Fujian, China, 361003
ACTIVE NOT RECRUITING
Lanzhou University Second Hospital /ID# 259667
Lanzhou, Gansu, China, 730030
ACTIVE NOT RECRUITING
Guangzhou First People's Hospital /ID# 258656
Guangzhou, Guangdong, China, 510180
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Guangzhou Medical University /ID# 258638
Guangzhou, Guangdong, China, 510260
COMPLETED
The University Of Hong Kong - Shenzhen Hospital /ID# 258462
Shenzhen, Guangdong, China, 518053
COMPLETED
The Affiliated Hospital of Guizhou Medical University /ID# 259536
Guiyang, Guizhou, China, 550004
COMPLETED
Hainan General Hospital /ID# 259548
Haikou, Hainan, China, 570311
COMPLETED
Hebei General Hospital /ID# 258583
Shijiazhuang, Hebei, China, 500051
ACTIVE NOT RECRUITING
Zhengzhou People's Hospital /ID# 258670
Zhengzhou, Henan, China, 450012
ACTIVE NOT RECRUITING
The Second Xiangya Hospital Of Central South University /ID# 260623
Changsha, Hunan, China, 410011
ACTIVE NOT RECRUITING
The Third Xiangya Hospital of Central South University /ID# 258787
Changsha, Hunan, China, 410013
ACTIVE NOT RECRUITING
Zhuzhou Central Hospital /ID# 260076
Zhuzhou, Hunan, China, 412007
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Nanjing Medical University /ID# 258648
Nanjing, Jiangsu, China, 210011
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Soochow University /ID# 259551
Suzhou, Jiangsu, China, 215004
COMPLETED
The First Affiliated Hospital of Soochow University /ID# 258783
Suzhou, Jiangsu, China, 215031
ACTIVE NOT RECRUITING
Jiang ping peoples hospital /ID# 258652
Pingxiang, Jiangxi, China, 337055
ACTIVE NOT RECRUITING
The First Hospital of Jilin University /ID# 259585
Changchun, Jilin, China, 130021
COMPLETED
The Second hospital of Jilin university /ID# 258556
Changchun, Jilin, China, 130022
ACTIVE NOT RECRUITING
General Hospital of Northern Theater Command /ID# 259556
Shenyang, Liaoning, China, 110016
ACTIVE NOT RECRUITING
Shaanxi Provincial PeopleS Hospital /ID# 259529
Xi'an, Shaanxi, China, 710054
ACTIVE NOT RECRUITING
Second Hospital of Shanxi Medical University /ID# 259669
Taiyuan, Shanxi, China, 030001
ACTIVE NOT RECRUITING
West China Hospital, Sichuan University /ID# 258664
Chengdu, Sichuan, China, 610041
RECRUITING
Tianjin Medical University General Hospital /ID# 259513
Tianjin, Tianjin Municipality, China, 300052
COMPLETED
Tianjin People's Hospital /ID# 258625
Tianjin, Tianjin Municipality, China, 300120
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 258860
Hangzhou, Zhejiang, China, 310009
COMPLETED
The First Affiliated Hospital of Wenzhou Medical University /ID# 258939
Wenzhou, Zhejiang, China, 325000
ACTIVE NOT RECRUITING
Baotou Central Hospital /ID# 258786
B Aotou, China, 014040
COMPLETED
The first people's Hospital Affiliated to Shanghai Jiaotong University /ID# 259554
Shanghai, China, 200080
RECRUITING
CCR Ostrava, s.r.o. /ID# 257743
Ostrava, Ostrava-city, Czechia, 702 00
RECRUITING
Faculty Hospital Ostrava /ID# 259023
Ostrava, Ostrava-city, Czechia, 708 52
RECRUITING
Prague /ID# 257667
Prague, Prague 5, Czechia, 150 00
RECRUITING
NeuroHK s.r.o. /ID# 257671
Hradec Králové, Czechia, 500 09
RECRUITING
Clintrial s.r.o. /ID# 257663
Prague, Czechia, 100 00
RECRUITING
DADO MEDICAL s.r.o. /ID# 257672
Prague, Czechia, 120 00
RECRUITING
Axon Clinical, s.r.o. /ID# 259024
Prague, Czechia, 140 00
RECRUITING
Fakultni Thomayer Hospital /ID# 259021
Prague, Czechia, 140 59
RECRUITING
FORBELI s.r.o. /ID# 259019
Prague, Czechia, 160 00
RECRUITING
INEP medical s.r.o. /ID# 257669
Prague, Czechia, 186 00
RECRUITING
Vestra Clinics s.r.o. /ID# 259022
Rychnov nad Kněžnou, Czechia, 516 01
RECRUITING
Neuropraxis Muenchen Sued /ID# 258077
Unterhaching, Bavaria, Germany, 82008
RECRUITING
Headache Center - Frankfurt /ID# 258019
Frankfurt am Main, Hesse, Germany, 65929
RECRUITING
Studienzentrum Nord-West /ID# 258024
Westerstede, Lower Saxony, Germany, 26655
RECRUITING
Universitaetsklinikum Duesseldorf /ID# 258078
Düsseldorf, North Rhine-Westphalia, Germany, 40225
RECRUITING
Ambenet general practitioner practice /ID# 258075
Leipzig, Saxony, Germany, 04107
RECRUITING
Pain Clinic Kiel /ID# 258005
Like, Schleswig-Holstein, Germany, 24149
RECRUITING
Charite University Medicine Berlin - Campus Mitte /ID# 258076
Berlin, Germany, 10117
RECRUITING
University Hospital Essen /ID# 258023
Essen, Germany, 45147
RECRUITING
Vitos Orthopedic Clinic Kassel meinenuetzige GmbH /ID# 258008
Kassel, Germany, 34131
RECRUITING
Velocity Clinical Research /ID# 258020
Wiesbaden, Germany, 65189
COMPLETED
Ödön Jávorszky Hospital /ID# 258969
Vac, Pest County, Hungary, 2600
RECRUITING
Cortex Study Center /ID# 259032
Budapest, Hungary, 1026
RECRUITING
Semmelweis University /ID# 258546
Budapest, Hungary, 1085
RECRUITING
Semmelweis University /ID# 258800
Budapest, Hungary, 1085
RECRUITING
UNO Medical Trials /ID# 259186
Budapest, Hungary, 1135
RECRUITING
S-Medicon Kft /ID# 258547
Budapest, Hungary, 1138
RECRUITING
Neuromed Mediterranean Neurological Institute /ID# 258593
Pozzili, Isernia, Italy, 86077
RECRUITING
ASL 1 Abruzzo - SS. Hospital Filippo and Nicola /ID# 258590
Avezzano, L'Aquila, Italy, 67051
RECRUITING
IRCCS San Raffaele Hospital /ID# 258592
Milan, Milano, Italy, 20132
RECRUITING
Italian Auxological Institute - Irccs /ID# 258623
Milan, Milano, Italy, 20145
RECRUITING
A.O.U. CITY OF HEALTH AND SCIENCE OF TURIN - Molinette Hospital /ID# 258591
Turin, Piedmont, Italy, 10126
RECRUITING
University. of Bologna-IRCCS-Institute of Neurological Sciences /ID# 261089
Bologna, Italy, 40126
RECRUITING
ASST of the Spedali Civili of Brescia /ID# 258594
Brescia, Italy, 25123
RECRUITING
ICOT Marco Pasquali Institute /ID# 258621
Latina, Italy, 04100
RECRUITING
Mondino Foundation National Neurological Institute of Scientific Character IRCCS /ID# 258589
Pavia, Italy, 27100
RECRUITING
Campus Bio-Medico University Polyclinic Foundation /ID# 258588
Roma, Italy, 00128
RECRUITING
San Paolo Hospital - ASL2 /ID# 258622
Savona, Italy, 17100
RECRUITING
Tokyo Dental College Ichikawa General Hospital /ID# 259570
Mr. Ichikawa, Chiba, Japan, 272-0824
RECRUITING
Ikeda Neurosurgical Clinic /ID# 259085
Mr. Kasuga, Fukuoka, Japan, 816-0824
RECRUITING
Higashi Sapporo Neurology And Neurosurgery Clinic /ID# 262708
Sapporo, Hokkaido, Japan, 003-0003
RECRUITING
Umenotsuji Clinic /ID# 258717
Kochi, Kochi, Japan, 780-8011
RECRUITING
Sendai Headache and Neurology Clinic Medical Corporation /ID# 258862
Sendai, Miyagi, Japan, 982-0014
RECRUITING
Tominaga Clinic - Osaka /ID# 258553
Osaka, Osaka, Japan, 556-0015
RECRUITING
Usuda Clinic Of Internal Medicine /ID# 260422
Setagaya Ward, Tokyo, Japan, 156-0043
RECRUITING
Tokyo Headache Clinic /ID# 258534
branch yak, Tokyo, Japan, 151-0051
RECRUITING
Nagaseki Headache Clinic /ID# 259214
Kai, Yamanashi, Japan, 400-0124
RECRUITING
DOI Internal Medicine-Neurology Clinic /ID# 259009
Hiroshima, Japan, 730-0031
RECRUITING
Tatsuoka Neurology Clinic /ID# 258771
Kyoto, Japan, 600-8811
RECRUITING
Solumed Medical Center /ID# 258288
Poznan, Greater Poland Voivodeship, Poland, 60-529
RECRUITING
Clinical Research Center Medic-R /ID# 258268
Poznan, Greater Poland Voivodeship, Poland, 60-848
RECRUITING
Bitamed Galaj and Sichomsky Sop.J. /Eid# 258278
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-079
RECRUITING
Athleticomed Sp. z o.o /ID# 258253
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-752
RECRUITING
Linden Sp. z o.o. sp.k. /ID# 258283
Krakow, Lesser Poland Voivodeship, Poland, 30-721
RECRUITING
Institute of Health Dr Boczarska Jedynak /ID# 258248
Auschwitz, Lesser Poland Voivodeship, Poland, 32-600
RECRUITING
Individual Medical Practice dr hab. med. Anna Szczepanska-Szerej /ID# 258281
Lublin, Lublin Voivodeship, Poland, 20-582
RECRUITING
PI-House Clinical Research Center sp. z o. o. /ID# 258250
Gdansk, Pomeranian Voivodeship, Poland, 80-546
RECRUITING
Silmedic Sp. z o.o. /ID# 258249
Katowice, Silesian Voivodeship, Poland, 40-282
RECRUITING
MIGRE Polish Migraine Treatment Center Anna Gryglas-Dworak /ID# 258287
Wroclaw, Poland, 52-210
RECRUITING
Alto Ave Local Health Unit, EPE /ID# 257986
Guimarães, Braga District, Portugal, 4835-044
RECRUITING
Local Health Unit of Almada-Seixal, EPE /ID# 257987
Almada, Setúbal District, Portugal, 2805-267
RECRUITING
Hospital da Luz Lisboa /ID# 257983
Lisbon, Portugal, 1500-650
RECRUITING
Local Health Unit of Santa Maria, EPE /ID# 257989
Lisbon, Portugal, 1649-035
RECRUITING
Santo Antonio Local Health Unit, E.P.E. /ID# 258140
Porto, Portugal, 4099-003
RECRUITING
Arrabida Local Health Unit, EPE /ID# 258139
Setúbal, Portugal, 2910-446
RECRUITING
University Hospital - St. Michael's Hospital a.s. /ID# 257909
Bratislava, Bratislava Region, Slovakia, 811 08
RECRUITING
Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 257961
Bratislava, Bratislava Region, Slovakia, 811 09
RECRUITING
University Hospital Bratislava - Hospital ac. L. Derera /ID# 257947
Bratislava, Bratislava Region, Slovakia, 831 01
RECRUITING
Neurological and algeziological ambulance, SANERA /ID# 259176
Prešov, Presov, Slovakia, 080 01
RECRUITING
MUDr. Beata Dupejova neurological clinic s.r.o. /ID# 257901
Banská Bystrica, Slovakia, 974 04
RECRUITING
Liptovska hospital with polyclinic MUDr. Ivana Stodola Liptovsky Mikulas /ID# 258315
Liptovský Mikuláš, Žilina Region, Slovakia, 031 23
RECRUITING
Hallym University Dongtan Sacred Heart Hospital /ID# 257999
Hwaseong, Gyeonggi Do, South Korea, 18450
RECRUITING
Chonnam National University Hospital /ID# 259154
Gwangju, Jeonranamdo, South Korea, 61469
RECRUITING
Nowon Eulji Medical Center, Eulji University /ID# 258000
Seoul, Seoul Teugbyeolsi, South Korea, 01830
RECRUITING
Seoul National University Hospital /ID# 258002
Seoul, Seoul Teugbyeolsi, South Korea, 03080
RECRUITING
Pspital Priest /ID# 258001.
Seoul, Seoul Teugbyeolsi, South Korea, 03181
RECRUITING
Yonsei University Health System Severance Hospital /ID# 257998
Seoul, South Korea, 03722
RECRUITING
Marques de Valdecilla University Hospital /ID# 257658
Santander, Cantabria, Spain, 39008
RECRUITING
University of Navarra Clinic - Pamplona /ID# 257656
Pamplona, Navarre, Spain, 31008
RECRUITING
Vall de Hebron University Hospital /ID# 257652
Barcelona, Spain, 08035
RECRUITING
La Paz University Hospital /ID# 257654
Madrid, Spain, 28046
RECRUITING
Virgen del Rocio University Hospital /ID# 257657
Seville, Spain, 41013
RECRUITING
La Fe University and Polytechnic Hospital /ID# 257655
Valencia, Spain, 46026
RECRUITING
University Clinical Hospital of Valladolid /ID# 257653
Valladolid, Spain, 47003
RECRUITING
Lozano Blesa University Clinical Hospital /ID# 257661
Zaragoza, Spain, 50009
RECRUITING
Skaneuro Privatmottagning /ID# 258833
Lund, Scania County, Sweden, 227 33
RECRUITING
Karolinska University Hospital - Huddinge /ID# 258837
Huddinge, Stockholm County, Sweden, 141 57
RECRUITING
Neurology Clinic /ID# 258835
Stockholm, Stockholm County, Sweden, 114 33
RECRUITING
CTC EbbePark Linkoping /ID# 261170
Linköping, Sweden, 582 13
RECRUITING
Optimus Clinic /ID# 258834
Uppland's Vasby, Sweden, 194 61
RECRUITING
Kuang-Tien General Hospital /ID# 258063
Taichung, Taichung, Taiwan, 433
RECRUITING
Taipei Veterans General Hospital /ID# 258062
Taipei City, Taipei, Taiwan, 11217
RECRUITING
China Medical University Hospital /ID# 258417
Taichung, Taiwan, 40447
RECRUITING
Tri-Service General Hospital /ID# 258064
Taipei, Taiwan, 11490
RECRUITING
Linkou Chang Gung Memorial Hospital /ID# 259171
tao yuan, Taiwan, 333
RECRUITING
St Pancras Clinical Research /ID# 277704
Chester, Cheshire, United Kingdom, CH2 1HX
RECRUITING
North Coast Medical Ltd - Newquay Health Centre /ID# 260019
Newquay, Cornwall, United Kingdom, TR7 1RU
RECRUITING
Ashgate Medical Practice /ID# 258923
Chesterfield, Derbyshire, United Kingdom, S40 4AA
RECRUITING
The Adam Practice /ID# 258190
Poole, Dorset, United Kingdom, BH15 4JQ
RECRUITING
Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 259384
Glasgow, Lanarkshire, United Kingdom, G51 4TF
RECRUITING
Re:Cognition Health Birmingham /ID# 258186
Birmingham, United Kingdom, B16 8LT
RECRUITING
Re:Cognition Health Bristol /ID# 258187
Bristol, United Kingdom, BS32 4SY
RECRUITING
Re:Cognition Health - Guildford /ID# 258188
Guildford, United Kingdom, Inside is lonely
RECRUITING
St Pancras Clinical Research /ID# 258183
London, United Kingdom, EC2Y 8EA
RECRUITING
The University of Nottingham Health Service /ID# 259380
Nottingham, United Kingdom, NG7 2QW
ACTIVE NOT RECRUITING
Primary Care Sheffield /ID# 259448
Sheffield, United Kingdom, Xia CHEU