AbbVie
A migraine attack is a moderate or severe headache that usually occurs on one side of the head and is often accompanied by throbbing, sensitivity to light, sensitivity to sound, nausea, or other symptoms. The main goal of the study is to see if atogepant is effective, safe, and well-tolerated in treating migraine attacks quickly. Atogepant is a medicine currently approved for the preventive treatment of migraine in adults and has been shown to be effective and well tolerated when taken daily to prevent migraine attacks. This study includes double-blind phase means that neither the participants nor the study doctors know who is given which study treatment (atogepant or placebo) followed by an open-label phase meaning that both participants and study doctors know which study treatment is given. All participants will receive atogepant during the open-label part of the study. This study will include 1300 participants aged 18-75 years with a history of migraine at approximately 160 sites across the world. All participants will receive both atogepant and placebo to treat qualifying migraines. At the start of the study, participants will be randomized to 1 of 4 dosing sequences to determine when they will receive atogepant and when they will receive placebo during the study. After treating 4 qualifying migraine attacks, participants will receive open-label atogepant for any additional migraine attacks they have until the end of the study (Week 24). There may be a bigger responsibility for participants in this study than there would be in participants receiving standard of care treatment. participants will attend regular visits during the study at a hospital or clinic, as well as telephone visits, and the effects of treatment will be checked by completion of questionnaires in an electronic diary, medical assessments, blood tests, and checking for side effects.
Migraine
Atogepant
Placebo for Atogepant
PHASE3
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 1300 participants |
| Masking : | QUADRUPLE |
| Primary Purpose : | TREATMENT |
| Official Title : | Randomized, Double-blind, Placebo-Controlled, Multiple-Attack Study With an Open-Label Extension to Evaluate the Efficacy, Safety, Tolerability, and the Consistency of Effect of Atogepant for the Acute Treatment of Migraine (ECLIPSE) |
| Actual Study Start Date : | 2024-03-25 |
| Estimated Primary Completion Date : | 2025-09 |
| Estimated Study Completion Date : | 2025-11 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years to 75 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
University Hospital Antwerp /ID# 257582
Edegem, Antwerp, Belgium, 2650
RECRUITING
University Hospital Brussels /ID# 257584
Throw, Brussels-Capital, Belgium, 1090
RECRUITING
Jessa Hospital /ID# 257578
Hasselt, Limburg, Belgium, 3500
RECRUITING
Ezz Centa Tower /as# 257585
Brugge, Belgium, 8000
RECRUITING
AZ Groeninge /ID# 257586
Kortrijk, Belgium, 8500
RECRUITING
CHR de la Citadelle /ID# 257587
Liege, Belgium, 4000
RECRUITING
H.-Hartziekenhuis Lier /ID# 257577
Lier, Belgium, 2500
RECRUITING
Cabinet Prive Dr Sava /Id# 257581
Saint-Nicolas, Belgium, 4420
ACTIVE NOT RECRUITING
The first affiliated hospital of bengbu medical college /ID# 258758
Bengbu, Anhui, China, 233004
COMPLETED
Beijing Friendship Hospital /ID# 258830
Beijing, Beijing, China, 100032
ACTIVE NOT RECRUITING
Xuanwu Hospital Capital Medical University /ID# 258510
Beijing, Beijing, China, 100053
ACTIVE NOT RECRUITING
Peking University Third Hospital /ID# 259573
Beijing, Beijing, China, 100191
ACTIVE NOT RECRUITING
Chinese PLA General Hospital /ID# 257540
Beijing, Beijing, China, 100853
ACTIVE NOT RECRUITING
Peking University First Hospital /ID# 258672
ξ into district, Beijing, China, 100034
ACTIVE NOT RECRUITING
Fujian Medical University Union Hospital /ID# 259575
F U-axis, Fujian, China, 350001
ACTIVE NOT RECRUITING
The First Affiliated Hospital of Xiamen University /ID# 259576
Xiamen, Fujian, China, 361003
ACTIVE NOT RECRUITING
Lanzhou University Second Hospital /ID# 259667
Lanzhou, Gansu, China, 730030
ACTIVE NOT RECRUITING
Guangzhou First People's Hospital /ID# 258656
Guangzhou, Guangdong, China, 510180
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Guangzhou Medical University /ID# 258638
Guangzhou, Guangdong, China, 510260
COMPLETED
The University Of Hong Kong - Shenzhen Hospital /ID# 258462
Shenzhen, Guangdong, China, 518053
COMPLETED
The Affiliated Hospital of Guizhou Medical University /ID# 259536
Guiyang, Guizhou, China, 550004
ACTIVE NOT RECRUITING
Hainan General Hospital /ID# 259548
Haikou, Hainan, China, 570311
COMPLETED
Hebei General Hospital /ID# 258583
Shijiazhuang, Hebei, China, 500051
ACTIVE NOT RECRUITING
Zhengzhou People's Hospital /ID# 258670
Zhengzhou, Henan, China, 450012
ACTIVE NOT RECRUITING
The Second Xiangya Hospital of Central South University /ID# 260623
Changsha, Hunan, China, 410011
ACTIVE NOT RECRUITING
The Third Xiangya Hospital of Central South University /ID# 258787
Changsha, Hunan, China, 410013
ACTIVE NOT RECRUITING
Zhuzhou Central Hospital /ID# 260076
Zhuzhou, Hunan, China, 412007
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Nanjing Medical University /ID# 258648
Nanjing, Jiangsu, China, 210011
ACTIVE NOT RECRUITING
The Second Affiliated Hospital of Soochow University /ID# 259551
Suzhou, Jiangsu, China, 215004
COMPLETED
The First Affiliated Hospital of Soochow University /ID# 258783
Suzhou, Jiangsu, China, 215031
ACTIVE NOT RECRUITING
JiangSystem ping people hospital /ID# 258652
Pingxiang, Jiangxi, China, 337055
ACTIVE NOT RECRUITING
The First Hospital of Jilin University /ID# 259585
Changchun, Jilin, China, 130021
COMPLETED
The Second hospital of Jilin university /ID# 258556
Changchun, Jilin, China, 130022
ACTIVE NOT RECRUITING
General Hospital of Northern Theater Command /ID# 259556
Shenyang, Liaoning, China, 110016
ACTIVE NOT RECRUITING
Shaanxi Provincial People'S Hospital /ID# 259529
XI AN, Shaanxi, China, 710054
ACTIVE NOT RECRUITING
Second Hospital of Shanxi Medical University /ID# 259669
Taiyuan, Shanxi, China, 030001
ACTIVE NOT RECRUITING
West China Hospital, Sichuan University /ID# 258664
Chengdu, Sichuan, China, 610041
RECRUITING
Tianjin Medical University General Hospital /ID# 259513
Tianjin, Tianjin, China, 300052
COMPLETED
Tianjin People's Hospital /ID# 258625
Tianjin, Tianjin, China, 300120
ACTIVE NOT RECRUITING
The second affiliated hospital of Zhejiang University school of medicine /ID# 258860
Hangzhou, Zhejiang, China, 310009
ACTIVE NOT RECRUITING
The First Affiliated Hospital of Wenzhou Medical University /ID# 258939
Wenzhou, Zhejiang, China, 325000
ACTIVE NOT RECRUITING
Baotou Central Hospital /ID# 258786
B's head, China, 014040
COMPLETED
The first people's Hospital Affiliated to Shanghai Jiaotong University /ID# 259554
Shanghai, China, 200080
RECRUITING
CCR Ostrava, s.r.o. /ID# 257743
Ostrava, Ostrava-mesto, Czechia, 702 00
RECRUITING
Faculty Hospital Ostrava /ID# 259023
Ostrava, Ostrava-mesto, Czechia, 708 52
RECRUITING
Praglandia / id # 257667
Prague, Prague 5, Czechia, 150 00
RECRUITING
NeuroHK s.r.o. /ID# 257671
Hradec Kralove, Czechia, 500 09
RECRUITING
Clintrial s.r.o. /ID# 257663
Prague 10, Czechia, 100 00
RECRUITING
FORBELI s.r.o. /ID# 259019
Prague, Czechia, 160 00
RECRUITING
Dado Medical S.R.O. /ID# 257672
Prague, Czechia, 120 00
RECRUITING
Axon Clinical, s.r.o. /ID# 259024
Prague, Czechia, 140 00
RECRUITING
Facultni Thomayer Hospital /ID# 259021
Prague, Czechia, 140 59
RECRUITING
INEP medical s.r.o. /ID# 257669
Prague, Czechia, 186 00
RECRUITING
Vestra Clinics s.r.o. /ID# 259022
Rychnov nad Knezná, Czechia, 516 01
RECRUITING
Neuropraxis Muenchen Sued /ID# 258077
Underhaching, Bayern, Germany, 82008
RECRUITING
Headache center - Frankfurt /ID# 258019
Frankfurt am Main, Hesse, Germany, 65929
RECRUITING
Studienzentrum Nord-West /ID# 258024
Westerstede, Lower Saxony, Germany, 26655
RECRUITING
Universitaetsklinikum Duesseldorf /ID# 258078
Düsseldorf, North Rhine-Westphalia, Germany, 40225
RECRUITING
Ambenet family practice /ID# 258075
Leipzig, Saxony, Germany, 04107
RECRUITING
Pain Clinic Kiel /ID# 258005
As, Schleswig-Holstein, Germany, 24149
RECRUITING
Charite University Medicine Berlin - Campus Mitte /ID# 258076
Berlin, Germany, 10117
RECRUITING
Universitaetsklinikum Essen /ID# 258023
Essen, Germany, 45147
RECRUITING
Vitos Orthopaedische Klinik Kassel Gemeinnuetzige GmbH /ID# 258008
Kassel, Germany, 34131
RECRUITING
Velocity Clinical Research /ID# 258020
Wiesbaden, Germany, 65189
COMPLETED
Ödön Jávorszky Hospital /id# 258969
Carrying, Pest, Hungary, 2600
RECRUITING
Cortex Study Center /ID# 259032
Budapest, Hungary, 1026
RECRUITING
Semmelweis University /ID# 258546
Budapest, Hungary, 1085
RECRUITING
Semmelweis University /ID# 258800
Budapest, Hungary, 1085
RECRUITING
UNO Medical Trials /ID# 259186
Budapest, Hungary, 1135
RECRUITING
S-MEDICON KFT /ID# 258547
Budapest, Hungary, 1138
RECRUITING
Mediterranean Neurological Institute Neuromed /Id# 258593
Pouce, Isernia, Italy, 86077
RECRUITING
ASL 1 Abruzzo - Hospital SS. Filippo and Nicola /Id# 258590
Avezzano, The eagle, Italy, 67051
RECRUITING
IRCCS San Raffaele Hospital /Id# 258592
Milan, Milano, Italy, 20132
RECRUITING
Italian Auxological Institute - IRCCS /ID# 258623
Milan, Milano, Italy, 20145
RECRUITING
A.O.U. City of Health and Science of Turin - Molinette /Id# 258591 Hospital
Torino, Piedmont, Italy, 10126
RECRUITING
University. of Bologna-Irccs-Institute of Neurological Sciences /Id# 261089
Bologna, Italy, 40126
RECRUITING
ASST of the Civil Spedali di Brescia /Id# 258594
Brescia, Italy, 25123
RECRUITING
ICOT Marco Pasquali Institute /Id# 258621
Latina, Italy, 04100
RECRUITING
Mondino National Neurological Institute Foundation of IRCCS /ID# 258589 scientific nature
Pavia, Italy, 27100
RECRUITING
Campus Bio-Medico Polyclinic University Foundation /Id# 258588
Roma, Italy, 00128
RECRUITING
San Paolo Hospital - ASL2 /Id# 258622
Savona, Italy, 17100
RECRUITING
Tokyo Dental College Ichikawa General Hospital /ID# 259570
Mr. Ichikawa, Chiba, Japan, 272-0824
RECRUITING
Ikeda Neurosurgical Clinic /ID# 259085
Mr. Kasuga, Fukuoka, Japan, 816-0824
RECRUITING
Higashi Sapporo Neurology And Neurosurgery Clinic /ID# 262708
Mr. Sapporo, Hokkaido, Japan, 003-0003
RECRUITING
Umenotsuji Clinic /ID# 258717
The late Mr. Chi, Kochi, Japan, 780-8011
RECRUITING
Sendai Headache and Neurology Clinic Medical Corporation /ID# 258862
Sendai-Yes, Miyagi, Japan, 982-0014
RECRUITING
Tominaga Clinic /ID# 258553
Saka, Osaka, Japan, 5560015
RECRUITING
Usuda Clinic Of Internal Medicine /ID# 260422
Setagaya-ku, Tokyo, Japan, 156-0043
RECRUITING
Tokyo Headache Clinic /ID# 258534
Shibuya-ku, Tokyo, Japan, 151-0051
RECRUITING
By Gasechi Headache Clinic / ID # 25924
Kai, Yamanashi, Japan, 400-0124
RECRUITING
DOI Internal Medicine-Neurology Clinic /ID# 259009
Hiroshima, Japan, 730-0031
RECRUITING
Tatsuoka Neurology Clinic /ID# 258771
Kyoto, Japan, 600-8811
RECRUITING
Hallym University Dongtan Sacred Heart Hospital /ID# 257999
Hwaseong, Gyeonggi do, Korea, Republic of, 18450
RECRUITING
Chonnam National University Hospital /ID# 259154
G.com - Four, Jeonranamdo, Korea, Republic of, 61469
RECRUITING
Nowon Eulji Medical Center, Eulji University /ID# 258000
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 01830
RECRUITING
Seoul National University Hospital /ID# 258002
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03080
RECRUITING
Pspital Priest /ID# 258001.
Seoul, Seoul Teugbyeolsi, Korea, Republic of, 03181
RECRUITING
Yonsei University Health System Severance Hospital /ID# 257998
Seoul, Korea, Republic of, 03722
RECRUITING
Bitameed Galaz E Sichomsky Sop. /Eid# 2021
Bydgoszcz, Kujawsko-Pomorskie, Poland, 85-079
RECRUITING
Athleticomed Sp. z o.o /ID# 258253
Bydgoszcz, Kujawsko-Pomorskie, Poland, 85-752
RECRUITING
Individual medical practice dr hab. med. Anna Szczepanska-Szerej /ID# 258281
Lublin, Lublin, Poland, 20-582
RECRUITING
Linden Sp. z o.o. sp.k. /ID# 258283
Krakow, Lesopolskie, Poland, 30-721
RECRUITING
Institute of Health Dr. Boczarska Jedynak /ID# 258248
Oświęcim, Lesopolskie, Poland, 32-600
RECRUITING
Centrum Kliniczne Research Pi-House sp.z o.o. /ID# 258250
Gdansk, Pomeranian, Poland, 80-546
RECRUITING
Silmedic Sp. z o.o. /ID# 258249
Katowice, Slaskie, Poland, 40-282
RECRUITING
Silumed Centrum Medyczne /ID# 258288
Poznan, Greater Poland, Poland, 60-529
RECRUITING
Clinical Research Center Sp. z.o.o. Medic-R sp. k /ID# 258268
Poznan, Greater Poland, Poland, 61-731
RECRUITING
Migre Polish Migraine Treatment Center Anna Gryglas-Dwage /ID# 258287
Wroclaw, Poland, 52-210
RECRUITING
Local Health Unit of the High Ave, EPE /ID# 257986
Guimaraes, Braga, Portugal, 4835-044
RECRUITING
Local Health Unit of Almada Seixal, EPE /ID# 257987
Almada, Setubal, Portugal, 2805-267
RECRUITING
Hospital da Luz Lisboa /ID# 257983
Lisboa, Portugal, 1500-650
RECRUITING
Local Health Unit of Santa Maria, EPE /ID# 257989
Lisboa, Portugal, 1649-035
RECRUITING
Local Health Unit of Santo Antonio, E.P.E. /Id# 258140
Porto, Portugal, 4099-003
RECRUITING
Local Health Unit of the Arrapea, EPE /ID# 258139
Setubal, Portugal, 2910-446
RECRUITING
University Hospital Bratislava - Hospital ak. L. Derera /ID# 257947
Bratislava, Bratislava region, Slovakia, 831 01
RECRUITING
Neurologica a Algeziology Ambulancia, Sanra /ID# 259176
Prešov, Presovsky region, Slovakia, 080 01
RECRUITING
Liptovska Hospital with Policlinic MUDr. Ivana Stodola Liptovsky Mikulas /ID# 258315
Liptovsky Mikulas, Zilinsky region, Slovakia, 031 23
RECRUITING
MUDr. Beata Dupejova neurological outpatient clinic s.r.o. /ID# 257901
Banska Bystrica, Slovakia, 974 04
RECRUITING
University Hospital - Hospital of Sloho Michael a.s. /ID# 257909
Bratislava, Slovakia, 811 08
RECRUITING
Poliklinika Bezrucova (Cliniq S.R.O.) /ID# 257961
Bratislava, Slovakia, 811 09
RECRUITING
Marques de Valdecilla /ID# 257658 University Hospital
Santander, Cantabria, Spain, 39008
RECRUITING
Clinic University of Navarra - Pamplona /ID# 257656
Pamplona, Navarra, Spain, 31008
RECRUITING
Vall d'Hebron University Hospital /ID# 257652
Barcelona, Spain, 08035
RECRUITING
La Paz University Hospital /ID# 257654
Madrid, Spain, 28046
RECRUITING
Virgen del Rocio University Hospital /ID# 257657
Sevilla, Spain, 41013
RECRUITING
UNIVERSITY AND POLITECNIC HOSPITAL LA FE /ID# 257655
Valencia, Spain, 46026
RECRUITING
Valladolid University Clinic Hospital /ID# 257653
Valladolid, Spain, 47003
RECRUITING
Lozano Blesa University Clinic Hospital /ID# 257661
Zaragoza, Spain, 50009
RECRUITING
Skaneuro Private Reception /ID# 258833
Lund, Skane Lan, Sweden, 227 33
RECRUITING
Karolinska University Hospital - Huddinge /ID# 258837
Huddinge, Stockholm Lan, Sweden, 141 57
RECRUITING
Neurology Clinic /ID# 258835
Stockholm, Stockholm Lan, Sweden, 114 33
RECRUITING
CTC ebbepark Linkoping /ID# 261170
Linköping, Sweden, 582 13
RECRUITING
Optimuskliniken /ID# 258834
Upplands Vasby, Sweden, 194 61
RECRUITING
Kuang-Tien General Hospital /ID# 258063
Taichung City, Taichung, Taiwan, 433
RECRUITING
Taipei Veterans General Hospital /ID# 258062
Taipei City, Taipei, Taiwan, 11217
RECRUITING
China Medical University Hospital /ID# 258417
Taichung, Taiwan, 40447
RECRUITING
Tri-Service General Hospital /ID# 258064
Taipei City, Taiwan, 11490
RECRUITING
Linkou Chang Gung Memorial Hospital /ID# 259171
Taoyuan City, Taiwan, 333
RECRUITING
North Coast Medical Ltd - Newquay Health Centre /ID# 260019
Newquay, Cornwall, United Kingdom, TR7 1RU
RECRUITING
The Adam Practice /ID# 258190
Poole, Dorset, United Kingdom, BH15 4JQ
RECRUITING
Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 259384
Glasgow, Lanarkshire, United Kingdom, G51 4TF
RECRUITING
Re:Cognition Health Birmingham /ID# 258186
Birmingham, United Kingdom, B16 8LT
RECRUITING
Re:Cognition Health Bristol /ID# 258187
Bristol, United Kingdom, BS32 4SY
RECRUITING
Royal Primary Care Ashgate /ID# 258923
Derbyshire, United Kingdom, S40 4aa
RECRUITING
Re:Cognition Health - Guildford /ID# 258188
Guildford, United Kingdom, Air
RECRUITING
St Pancras Clinical Research /ID# 258183
London, United Kingdom, EC2Y 8EA
RECRUITING
The University of Nottingham Health Service /ID# 259380
Nottingham, United Kingdom, Ng7 2qw
ACTIVE NOT RECRUITING
Primary Care Sheffield /ID# 259448
Sheffield, United Kingdom, Cheu