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NCT05712772 | Recruiting | Depression in Adolescence

Neuro-affective Response to Light in Depressed Adolescents and Young Adults
Sponsor:

University of Pittsburgh

Information provided by (Responsible Party):

Adriane Soehner

Brief Summary:

The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults? Participants will complete: A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses. A pupillometry test of sensitivity to blue vs red light Clinical interviews and surveys Screening measures for drug and alcohol use, MRI safety, and current pregnancy [if relevant] Home sleep tracking with sleep diary and actigraphy for one week

Condition or disease

Depression in Adolescence

Depression in Adults

Intervention/treatment

Blue Light

Red Light

Phase

Not Applicable

Study Type : Interventional
Estimated Enrollment : 80 participants
Masking : None (Open Label)
Primary Purpose : Other
Official Title : Neuro-affective Response to Light in Depressed Adolescents and Young Adults
Actual Study Start Date : June 14, 2023
Estimated Primary Completion Date : July 31, 2024
Estimated Study Completion Date : July 31, 2024
Arm Intervention/treatment

Experimental: Blue then Red Light

Blue light (480 nm) then Red light (640 nm)

Other: Blue Light

Other: Red Light

Experimental: Red Light then Blue Light

Red light (640 nm) then Blue light (480 nm)

Other: Blue Light

Other: Red Light
Ages Eligible for Study: 12 Years to 30 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • DSM-5 major depressive episode
  • (If <18yr) Parent or guardian can attend the baseline clinical interview
Exclusion Criteria
  • Unable to read and write in English
  • Intellectual disability.
  • Left or mixed handedness
  • Use of psychotropic medication other than stable Selective Serotonin Reuptake Inhibitor (SSRI) medication (> 2 months)
  • Lifetime bipolar disorder or schizophrenia, or substance/alcohol disorder in the past 3 months.
  • Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).
  • Factors influencing the ability to maintain a stable sleep schedule (i.e., shift work, severe sleep disorders, extremely late or early sleep schedule).
  • Severe medical illness, neurological disorders, or history of head trauma.
  • Current pregnancy or nursing
  • MRI contraindication (e.g., metals in the body, recent tattoo, claustrophobia)
  • Positive alcohol or substance use screen at MRI visit
Neuro-affective Response to Light in Depressed Adolescents and Young Adults

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Neuro-affective Response to Light in Depressed Adolescents and Young Adults

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Locations

Recruiting

United States, Pennsylvania

Western Psychiatric Hospital

Pittsburgh, Pennsylvania, United States, 15213