Organ surgery department, Lillebælt Hospital, Kolding
Malene Borgager Dissing
The aim of this project is to investigate the presence of bacteria in the gallbladder wall and the bile in patients undergoing cholecystectomy, to determine if the standard empirical antibiotic treatment used currently is effective against the most common pathogens.
Calculous Cholecystitis
Antibiotic Resistant Infection
Gallbladder Inflammation
Microbiological and histopathological investigation of bile and gallbladder wall specimens.
The investigators will compare two groups of patients; patients with acute calculous cholecystitis undergoing acute laparoscopic cholecystectomy and patients without cholecystitis undergoing elective laparoscopic cholecystectomy. Secondly, the investigators wish to investigate if the presence of bacteria correlates with the grade of inflammation, and whether this can predict when cholecystitis is caused by infection. In a clinical setting, this can provide important knowledge regarding the choice of antibiotics currently used to treat and prevent infection in the gallbladder. The investigators will conduct two studies, one investigating the bacteria in bile and in the gallbladder wall and the resistens of the bacteria to antibiotics and another study investigating the histopathology of the gallbladder wall to see if the bacteria present is the cause of inflammation or an actual infection.}}
| Study Type : | Observational |
| Estimated Enrollment : | 60 participants |
| Official Title : | Cholecystitis From a Microbiological and Histopathological Perspective |
| Actual Study Start Date : | April 1, 2023 |
| Estimated Primary Completion Date : | June 2025 |
| Estimated Study Completion Date : | October 2025 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Lillebælt Hospital
Cold weather, Denmark, 6000