University Hospital, Angers
Prospective study to decipher the clonal architecture of ASXL1-mutated primary and secondary myelofibrosis and its impact on prognosis
Myelofibrosis
Clonal architecture determination
Not Applicable
The clonal architecture of myelofibrosis patients is still little described. Inconsistent results in terms of the prognostic value of some mutations are observed in the literature, in particular concerning ASXL1 mutations. We assume that a better understanding of the clonal architecture of ASXL1-mutated myelofibrosis could help refining the prognostic impact of ASXL1 mutations. This study aims to evaluate a multicenter cohort of 50 patients. Blood of patients will be collected within 18 months of diagnosis. After 4 years of follow-up of the patient as part of his usual care, data on survival and leukemic transformation will be collected.}}
| Study Type : | Interventional |
| Estimated Enrollment : | 50 participants |
| Masking : | None (Open Label) |
| Primary Purpose : | Other |
| Official Title : | Clonal Architecture of ASXL1-mutated Myelofibrosis |
| Actual Study Start Date : | March 2023 |
| Estimated Primary Completion Date : | March 2025 |
| Estimated Study Completion Date : | March 2029 |
| Arm | Intervention/treatment |
|---|---|
|
Experimental: CLONEMF cohort |
Biological: Clonal architecture determination |
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
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Not yet recruiting
Chu Ungers
Angers, France,
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CH Cholet
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Bicetre Hospital
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Cornish CH
Quimper, France,
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CHRU Tours - Bretonneau Hospital
Tours, France,