Lots of University
Mostafa is very
The exact underlying mechanisms of ulcerative colitis (UC), an idiopathic, chronic inflammatory disease marked by diffused inflammation of the colon and rectum mucosa, are still unknown. Due to genetic, immune, and environmental factors, UC is highly dependent on cellular immune reactions and exaggerated inflammatory responses. The release of several cytokines, kinins, leukotrienes, platelet-activating factor (PAF), and reactive oxygen species is connected to immunological activity (ROS). Additionally, many of the cytokines will start an acute phase response, making the inflammation worse.
Inflammatory Bowel Diseases
Pentoxifylline 400 MG
Phase 2
| Study Type : | Interventional |
| Estimated Enrollment : | 50 participants |
| Masking : | Double |
| Masking Description : | double-blinded |
| Primary Purpose : | Treatment |
| Official Title : | Clinical Study to Evaluate the Possible Efficacy of Pentoxifylline in Patients With Ulcerative Colitis Treated With Mesalamine |
| Actual Study Start Date : | October 10, 2022 |
| Estimated Primary Completion Date : | October 20, 2024 |
| Estimated Study Completion Date : | February 20, 2025 |
| Arm | Intervention/treatment |
|---|---|
|
No Intervention: Control Group this group will take mesalamine 1 g three times daily |
|
|
Active Comparator: Pentoxifylline group his group will take mesalamine 1 g three times daily plus pentoxifylline 400 mg two times daily |
| Ages Eligible for Study: | 18 Years to 75 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Faculty of Medicine, Mansoura University
Mansoura, Egypt, 35511