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NCT05558384 | Recruiting | Cancer

Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors
Sponsor:

University of Colorado, Denver

Brief Summary:

This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise program in cancer survivors. This investigation attempts to isolate the influence of adiposity on these responses. We will enroll overweight, obese, and normal weight cancer survivors with a primary diagnosis of breast, prostate, or colorectal cancer who have completed all cancer-related treatment. Participants will engage in a 15-week aerobic exercise intervention with pre- and post-intervention assessments.

Condition or disease

Cancer

Overweight and Obesity

Intervention/treatment

Aerobic Exercise

Phase

Not Applicable

Study Type : Interventional
Estimated Enrollment : 20 participants
Masking : None (Open Label)
Primary Purpose : Treatment
Official Title : The Influence of Excess Adiposity on Cardiorespiratory, Insulin-like Growth Factor, and Metabolic Responses to a Standardized Aerobic Exercise Program in Cancer Survivors
Actual Study Start Date : December 1, 2024
Estimated Primary Completion Date : September 30, 2025
Estimated Study Completion Date : September 30, 2026
Arm Intervention/treatment

Experimental: Aerobic exercise

15-week standardized aerobic exercise intervention

Behavioral: Aerobic Exercise
Ages Eligible for Study: 21 Years to 79 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Primary cancer diagnosis of breast, prostate, or colorectal cancer
  • Completion of all cancer-related treatment > than 6 months prior and < 5 years prior to enrollment
  • Ability and willingness to participate in a supervised exercise program
  • All participants will be required to obtain a signed physician clearance to participate in exercise form prior to enrollment
Exclusion Criteria
  • Presence of a secondary active cancer diagnosis or metastatic disease
  • Any current cancer treatment (including hormonal treatment) or planned cancer treatment in the next 5 months
  • Greater than 100 min of self-reported regular exercise per week
  • BMI < 18.5 (underweight)
  • Any significant metabolic condition, such as diabetes. Individuals with pre-diabetes or metabolic syndrome will not be excluded, but this information will be recorded.
  • Any medical condition that would impact the safety of, or participation in, an exercise program or exercise testing, including
    • Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
    • Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
    • Pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
    • Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors

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Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors

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Locations

Recruiting

United States, Colorado

University of Colorado Hospital

Aurora, Colorado, United States, 80045