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NCT05553548 | Not yet recruiting | Alveolar Ridge Preservation

Alveolar Ridge Changes With Biologically Oriented Alveolar Ridge Preservation (BARP) After Tooth Extraction
Sponsor:

Cairo University

Information provided by (Responsible Party):

Their names are Mohammed Osama Al-Gammal

Brief Summary:

After tooth extraction, the alveolar process undergoes substantial horizontal and vertical resorption specifically in non-molar sites, where horizontal, vertical mid- facial, and mid-lingual ridge reduction could occur . These dimensional changes are clinically relevant, as they may affect dental implant placement and compromise soft tissue aesthetics. Alveolar ridge preservation (ARP) is based on the application of a bone replacement graft into the extraction socket & collagen membrane/plug. Recent systematic reviews have shown that ARP may limit bone resorption to about 50% of what is normally observed in case of unassisted healing . This finding indicates that ARP is effective; but at the same time, it underlines the potential for improvement.

Condition or disease

Alveolar Ridge Preservation

Intervention/treatment

biologically oriented alveolar ridge preservation

xenogenic bone graft in entire (apico-coronal) extension

Phase

Not Applicable

Detailed Description:

In ARP procedures based on socket grafting, the use of a bone replacement graft would prevent up to a 30% of volume reduction in the coronal third. Whereas it has limited effect in the remaining middle-apical thirds . Since grafting of the alveolus often results in the persistence of residual graft particles embedded into the newly formed bone with a delay in the rate of bone deposition and mineralization the need to extend the grafting procedure apical to the coronal third of the socket seems questionable. Based on these considerations, a novel, simplified technique, namely, the Biologically-oriented Alveolar Ridge Preservation (BARP) for ARP that restricts socket grafting to the coronal portion of the socket was presented .}}

Study Type : Interventional
Estimated Enrollment : 36 participants
Masking : Double
Primary Purpose : Treatment
Official Title : Alveolar Ridge Changes With Biologically Oriented Alveolar Ridge Preservation (BARP) After Tooth Extraction : A Randomized Clinical Trial
Actual Study Start Date : October 20, 2022
Estimated Primary Completion Date : January 5, 2023
Estimated Study Completion Date : January 10, 2024
Arm Intervention/treatment

Experimental: biologically oriented alveolar ridge preservation (BARP) group

for alveolar ridge preservation using demineralized bovine bone graft layer in the most coronal part of the extracted tooth socket

Procedure: biologically oriented alveolar ridge preservation

Active Comparator: bone graft (entire apico-coronal extension)

alveolar ridge preservation using demineralized bovine bone graft on the entire apico-coronal extension.

Procedure: xenogenic bone graft in entire (apico-coronal) extension
Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Criteria
Inclusion Criteria
  • Adults 18 years old or more.
  • Patients with good oral hygiene, defined as a full-mouth plaque score ≤25% (O'Leary et al., 1972).
  • Patients who need alveolar ridge preservation after tooth extraction at one or two sites in the aesthetic zone (incisor, cuspid, or premolar area in the maxilla or mandible) with >50% buccal bone present following tooth extraction (Eeckhout et al., 2022) .
  • One or two neighboring teeth.
  • Compliant patients who will sign an informed consent and agree to the follow up period.
Exclusion Criteria
  • • Uncontrolled systemic disease
  • Past or current smoking
  • Untreated or unstable periodontitis
  • Untreated caries lesions.
Alveolar Ridge Changes With Biologically Oriented Alveolar Ridge Preservation (BARP) After Tooth Extraction

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Alveolar Ridge Changes With Biologically Oriented Alveolar Ridge Preservation (BARP) After Tooth Extraction

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Locations

Not yet recruiting

Egypt, Giza

Cairo University

Cairo, Giza, Egypt, 12613