St. Jude Children's Research Hospital
Survivors of childhood cancer are at greater risk for long-term cognitive impairments that include attention, executive function, intelligence, memory, and processing speed. The participants are a survivor of acute lymphoblastic leukemia (ALL) or Hodgkin's lymphoma (HL). Because of your treatment the participant may have developed trouble with thinking and learning. Primary Objective To evaluate the feasibility of using home-based tPBM paired with remote cognitive training to improve cognitive performance in survivors of ALL and HL. Secondary Objectives To estimate the potential efficacy of alpha and gamma frequency tPBM on cognitive performance in survivors of ALL and HL. Exploratory Objectives To estimate the effects of home-based tPBM paired with remote cognitive training on patient reported symptoms of executive dysfunction, sleep, depression, anxiety, fatigue, and pain in survivors of ALL and HL.
ALL
Hodgkin Lymphoma
Cancer
Survivorship
Transcranial photobiomodulation (tPBM) - Mobile System
Not Applicable
Survivors with ALL and HL with identified executive function impairment will be randomized to receive stimulation with alpha tPBM + cognitive training, gamma tPBM + cognitive training or sham tPBM + cognitive training three days per week for a 2-month intervention period The tPBM will be applied to nodes in the default mode network.}}
Study Type : | Interventional |
Estimated Enrollment : | 30 participants |
Masking : | Triple |
Masking Description : | The proposed study is a double-blind, randomized placebo-controlled pilot study of remotely delivered tPBM paired with cognitive training. |
Primary Purpose : | Device Feasibility |
Official Title : | Use of Transcranial Photobiomodulation to Improve Cognition and Self-Reported Outcomes in Survivors of Childhood Cancer |
Actual Study Start Date : | January 5, 2023 |
Estimated Primary Completion Date : | June 2024 |
Estimated Study Completion Date : | February 2025 |
Arm | Intervention/treatment |
---|---|
Experimental: alpha tPBM + cognitive training three days per week for a 2-month intervention period (5 ALL and 5 HL) |
Device: Transcranial photobiomodulation (tPBM) - Mobile System |
Experimental: gamma tPBM + cognitive training three days per week for a 2-month intervention period (5 ALL and 5 HL) |
Device: Transcranial photobiomodulation (tPBM) - Mobile System |
Experimental: sham tPBM + cognitive training Sham stimulations will act as the control for this study three days per week for a 2-month intervention period (5 ALL and 5 HL) |
Device: Transcranial photobiomodulation (tPBM) - Mobile System |
Ages Eligible for Study: | 18 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
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Recruiting
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105