Sohag University
Fatima Mohammed Hamdan
Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell. Retinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders. the investigator hopes to assess prognosis of SCC & BCC by using RXR-α biomarker & attempts to use it in the treatment.
Non-melanoma Skin Cancer
Study Type : | Observational |
Estimated Enrollment : | 50 participants |
Official Title : | Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma: An Immunohistochemical Study. |
Actual Study Start Date : | December 2022 |
Estimated Primary Completion Date : | September 2023 |
Estimated Study Completion Date : | December 2023 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | |
Sexes Eligible for Study: | All |
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