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NCT05372549 | Recruiting | Fertility Preservation


Correlation of Oxidative Stress and Oocyte Quality in Fertility Preservation
Sponsor:

Clinique Ovo

Brief Summary:

Whether it is for oncology or personal reasons, fertility preservation allows participants to preserve their oocytes (eggs) at their current age and condition for a better chance of having a baby in the future. In order to proceed with fertility preservation, participants will need to undergo in vitro fertilization (IVF), which is standard practice, and take stimulation medication to stimulate production of more follicles. The combination of both Rekovelle and Menopur for fertility preservation may increase ovarian response to stimulation and increase the number of oocytes retrieved to give better chances of embryos once the oocytes will be fertilized. The goal in this study is to understand the effect of oxydative stress on the quality of oocytes. For the purpose of the study and to evaluate this connection, serum levels of oxidative stress and cf-DNA in your blood will be measured. Oocyte quality will also be assessed with Magenta, a prediction tool utilizing artificial intelligence (AI). This method is non-invasive and has no risks on the oocytes.

Condition or disease

Fertility Preservation

Intervention/treatment

Oxidative stress

cf-DNA

MAGENTA AI

Phase

Not Applicable

Study Type : Interventional
Estimated Enrollment : 180 participants
Masking: None (Open Label)
Primary Purpose: Other
Official Title: Correlation of Oxidative Stress and Oocyte Quality in Fertility Preservation
Actual Study Start Date : June 1, 2022
Estimated Primary Completion Date : July 31, 2024
Estimated Study Completion Date : December 31, 2024
Arm Intervention/treatment

Other: Oncology preservation

Other: Oxidative stress

Other: cf-DNA

Other: MAGENTA AI

Other: Social (elective) preservation

Other: Oxidative stress

Other: cf-DNA

Other: MAGENTA AI

Ages Eligible for Study: 18 Years to 37 Years
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • - Women 18 to 37 years of age inclusively eligible for fertility preservation for either social or oncology reason
Exclusion Criteria
  • Pregnancy and lactation
  • Uncontrolled thyroid or adrenal dysfunction
  • Tumours of the hypothalamus or pituitary gland
  • Ovarian enlargement not due to polycystic ovarian syndrome
  • Gynaecological haemorrhages of unknown aetiology
  • Endometriosis stage III/IV
  • Use of hormonal preparations (except for thyroid medication) during the last menstrual cycle
  • Use of Coenzyme Q10 during the stimulation cycle
  • Renal and/or hepatic impairment
  • Hypersensitivity to any active ingredient or excipients in follitropin delta and/or HP-hMG

Correlation of Oxidative Stress and Oocyte Quality in Fertility Preservation

Location Details


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Correlation of Oxidative Stress and Oocyte Quality in Fertility Preservation

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Not yet recruiting

Canada, British Columbia

Olive Fertility Centre

Vancouver, British Columbia, Canada, V5Z 3X7

Not yet recruiting

Canada, Ontario

Ottawa Fertility Centre

Ottawa, Ontario, Canada, K2C 3V4

Recruiting

Canada, Quebec

Clinique Ovo

Montreal, Quebec, Canada, H4P 2S4

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