Spectrum Health - Lakeland
The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort. Morphine has been shown to worsen outcomes in heart attack patients due to reduction of oral anti-platelet agent effectiveness and so many providers have switches to using fentanyl. However, it is largely unknown whether fentanyl has similar effects.
Fentanyl
Platelet Reactivity
Morphine
Fentanyl
Early Phase 1
Patients presenting to the emergency department with chest discomfort who are being administered aspirin will be offered enrollment in this study. At the time of their zero and two hour troponin we will also draw platelet aggregration studies to determine the effects of aspirin upon platelets. Narcotic medicines slow the absorption of aspirin. Morphine has therefore been shown to decrease the effectiveness of aspirin. Many providers therefore use fentanyl instead, however little is known about the effects of fentanyl upon aspirin. We will therefore compare the platelet reactivity of patients receiving morphine, fentanyl, or no narcotics}}
| Study Type : | Interventional |
| Estimated Enrollment : | 100 participants |
| Masking : | Double |
| Primary Purpose : | Treatment |
| Official Title : | A Comparison of PLAtelet Response to Aspirin Between Emergency Department Patients With Chest Pain Receiving Fentanyl or Morphine (PLAAFM) |
| Actual Study Start Date : | August 31, 2022 |
| Estimated Primary Completion Date : | May 2024 |
| Estimated Study Completion Date : | May 2024 |
| Arm | Intervention/treatment |
|---|---|
|
No Intervention: Control not receiving any narcotics |
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Experimental: Morphine the second group will be those receiving morphine |
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Experimental: Fentanyl the 3rd group will be those receiving fentanyl |
| Ages Eligible for Study: | 18 Years to 65 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Spectrum Health Lakeland
Saint Joseph, road cancer, United States, 49085