Pamela Youde Nethersole Eastern Hospital
Fergus Wong Kai Chuen
Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases. Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries. Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study. However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.
Olfaction Disorders
Smell Disorders
Anosmia
Hyposmia
Olfactory Impairment
Smell Loss
Smell Dysfunction
Olfactory Training
Control
Not Applicable
Design Prospective double-blinded randomized control trial. Study Period 1/7/2022 - 30/6/2024 for case recruitment. Suitable patient will be recruited. Informed consent will be signed. Objective smell assessment will be done using the University of Pennsylvania Smell Identification Test (UPSIT) and Butanol Threshold Test (BTT). Subjective quality of life score will be obtained by Sino-Nasal Outcome Test (SNOT-22). Subjective smell and taste assessment will be assessed by Visual Analogue Scale (VAS). Patient will be randomized into treatment group and control group using computer generated list by an independent nursing staff. Doctors and the patients will be blinded during the study.}}
| Study Type : | Interventional |
| Estimated Enrollment : | 80 participants |
| Masking : | Single |
| Masking Description : | Randomly assigned by computer into treatment group and control group |
| Primary Purpose : | Treatment |
| Official Title : | Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population |
| Actual Study Start Date : | July 1, 2022 |
| Estimated Primary Completion Date : | June 30, 2025 |
| Estimated Study Completion Date : | June 30, 2025 |
| Arm | Intervention/treatment |
|---|---|
|
Experimental: Treatment arm Olfactory training by neurological chemosensory stimulation using aromatic substances delivered via diffusers. Four aromatic substances will be used. Each substance will be given for 20 seconds sequentially, providing a total of 80 seconds of olfactory stimulation three times per day for 3 months. |
Other: Olfactory Training |
|
Placebo Comparator: Control arm Same diffuser will be given to control group. All of the four essential oils will be replaced by normal saline using the same packing. Same treatment regime of 20 seconds for each diffuser three times per day for 3 months will be instructed to control group patients. |
Other: Control |
| Ages Eligible for Study: | 18 Years to 70 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong,