University Medical Center Groningen
Bariatric surgery (BS) is currently the most effective treatment in severe obesity. However, a considerable percentage of patients undergoing BS fail to lose sufficient weight or regain weight after initial weight loss during long-term follow-up, which may be attributed to personality traits and pathological eating behaviour. Previous positron emission tomography (PET) studies have shown reduced dopamine D2 receptor availability in obese patients and upregulation of this availability following successful BS in the brain's reward system. Dopamine D2 receptor availability in patients with unsuccessful BS has not been investigated to date.
Obesity
standardized liquid mixed meal Nutridrink®
Not Applicable
Study Type : | Interventional |
Estimated Enrollment : | 30 participants |
Masking : | None (Open Label) |
Primary Purpose : | Other |
Official Title : | PET-study on the Role of the Reward System in Weight Loss After Bariatric Surgery |
Actual Study Start Date : | December 1, 2022 |
Estimated Primary Completion Date : | March 1, 2024 |
Estimated Study Completion Date : | March 1, 2024 |
Arm | Intervention/treatment |
---|---|
Experimental: Unsuccessful BS (Total Weight Loss (TWL) < 20%) Fifteen who had unsuccessful BS (Total Weight Loss (TWL) < 20%) |
Other: standardized liquid mixed meal Nutridrink® |
Experimental: Successful BS (TWL > 25%). Fifteen who had successful BS (TWL > 25%). |
Other: standardized liquid mixed meal Nutridrink® |
Ages Eligible for Study: | 18 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
MCL
Leeuwarden, Netherlands,