Stanford University
David Spiegel
This study will investigate the anti-anhedonic efficacy of a novel neurostimulation strategy termed accelerated intermittent theta burst stimulation (aiTBS) in participants with treatment resistant depression (TRD).
Treatment Resistant Depression
Active TBS-DLPFC
Active TBS-DMPFC
Sham TBS-DLPFC or DMPFC
Not Applicable
Repetitive transcranial magnetic stimulation (rTMS) is an established therapy for treatment-resistant depression. The approved method for treatment is 10Hz stimulation for 40 min over the left dorsolateral prefrontal cortex (L-DLPFC). This methodology has been effective in real world situations. The limitations of this approach include the duration of the treatment (approximately 40 minutes per treatment session, 5 days per week, for 4-8 weeks). Recently, the investigators have pursued modifying the treatment parameters to reduce treatment times with an accelerated treatment paradigm. This study aims to further study the accelerated protocol and examine changes in neuroimaging biomarkers.
Study Type : | Interventional |
Estimated Enrollment : | 100 participants |
Masking: | Quadruple |
Primary Purpose: | Treatment |
Official Title: | Personalized Therapeutic Neuromodulation for Anhedonic Depression |
Actual Study Start Date : | May 31, 2022 |
Estimated Primary Completion Date : | December 2024 |
Estimated Study Completion Date : | December 2024 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Active TBS-DLPFC The active group will receive theta-burst TMS stimulation. |
Device: Active TBS-DLPFC |
Active Comparator: Active TBS-DMPFC The active group will receive theta-burst TMS stimulation. |
Device: Active TBS-DMPFC |
Sham Comparator: Sham Comparator: Sham TBS-DLPFC or DMPFC The sham group will receive sham theta-burst TMS stimulation. |
Device: Sham TBS-DLPFC or DMPFC |
Ages Eligible for Study: | 18 Years to 80 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine
Stanford, California, United States, 94305