University Medical Center Groningen
J.S.F. Sanders
Rationale: Despite improved patient and graft survival in renal transplant recipients, still 20% of the patients reaches end-stage renal disease within 5 years after transplantation. Antibody-mediated rejection (ABMR) is one of the major causes of early graft loss and perhaps even more important of late deterioration of graft function Objective: Evaluate the occurrence of antibody mediated rejection (ABMR) and mixed ABMR and cellular/ T-cell mediated rejection (TCMR), in patients treated with the currently prevailing immunosuppressive regimens, and relate them to outcome (graft survival, function, proteinuria, histology) Study design: Clinical cohort study. Study population: patients of >18 years old, about to receive a post mortal of living donor renal transplant with an immunological high risk for ABMR. Main study parameters/endpoints: main study endpoints are the occurrence of ABMR, mixed ABMR/TCMR and renal function after 1 year of follow-up. The main study parameter will be mapping the immune system, including B-cells, (non-)HLA antibodies, interaction between B-cells and T follicular helper cells, and complete immune profiling.
Antibody-mediated Rejection
Kidney Transplantation
Immunosuppression
Kidney Transplantation
Immunosuppression
Nephrectomy (kidney donation)
Study Type : | Observational |
Estimated Enrollment : | 225 participants |
Official Title : | Incidence, Course and Outcome of Cellular and Antibody-mediated Rejection in Immunological High-risk Kidney Transplantation, a Prospective Cohort PROCARE2 Study |
Actual Study Start Date : | January 1, 2022 |
Estimated Primary Completion Date : | January 1, 2025 |
Estimated Study Completion Date : | March 1, 2026 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | 18 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Recruiting
Academic Medical Centre
Amsterdam, Netherlands,
Recruiting
University Medical Center Groningen
Groningen, Netherlands,
Recruiting
Leiden University Medical Center
Leiden, Netherlands,
Recruiting
Radboud University Hospital
Nijmegen, Netherlands,
Recruiting
Erasmus MC
Rotterdam, Netherlands,
Recruiting
UMC
Utrecht, Netherlands,