Thammasat University
Kittipong Wattanasirisombat
The purpose of this study is to compare the efficacy of Intra-articular corticosteroid injection between Betamethasone (Diprospan) and Triamcinolone acetonide for treatment of knee osteoarthritis
Knee Osteoarthritis
Betamethasone Dipropionate / Betamethasone Sodium Phosphate
Triamcinolone Acetonide 40mg/mL
Phase 4
After being informed about the study and potential risks, all patients giving written informed consent will be chosen for eligibility for the study entry. At day 0 (before intra-articular injection), patients who meet the eligibility criteria will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to Betamethasone (Diprospan 1 ml) or Triamcinolone acetonide (40 mg) single intra-articular injection}}
| Study Type : | Interventional |
| Estimated Enrollment : | 105 participants |
| Masking : | Quadruple |
| Masking Description : | Participant and Care Provider will not know which drug is injected to the investigated knee because the opaque syringe is used to inject. Investigator and outcomes assessor will not known the group of participants because randomization, they only know the number of the participants. |
| Primary Purpose : | Treatment |
| Official Title : | A Comparative Study of Betamethasone (Diprospan) and Triamcinolone Acetonide as Single Intra-Articular Injection in Knee Osteoarthritis, A Double-Blinded, Randomized Controlled Trial |
| Actual Study Start Date : | January 1, 2022 |
| Estimated Primary Completion Date : | June 30, 2024 |
| Estimated Study Completion Date : | June 30, 2024 |
| Arm | Intervention/treatment |
|---|---|
|
Experimental: Betamethasone (Diprospan) Participant received single intra-articular Betamethasone Dipropionate / Betamethasone Sodium Phosphate 1 ml |
Drug: Betamethasone Dipropionate / Betamethasone Sodium Phosphate |
|
Active Comparator: Triamcinolone acetonide Participant received single intra-articular Triamcinolone acetonide 40 mg |
Drug: Triamcinolone Acetonide 40mg/mL |
| Ages Eligible for Study: | |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Thammasat University Hospital
Khlong Luang, Pathumthani, Thailand, 12120