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NCT05139836 | Recruiting | Atopic Dermatitis


A Study to Assess Disease Activity in Adolescent and Adult Participants With Atopic Dermatitis Who Receive Oral Upadacitinib Tablets in a Real-World Setting
Sponsor:

AbbVie

Brief Summary:

Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study will assess the real-world effectiveness of upadacitinib on early and sustained response along adolescent and adult participants with AD. This study also aims to understand upadacitinib utilization patterns in real-world clinical practice. Upadacitinib (RINVOQ) is approved in the EU for the treatment of moderate to severe AD in adults and adolescents 12 years and older who are candidates for systemic therapy. Approximately 772 adolescent and adult participants with AD will be enrolled at up to 200 sites in Germany. Participants will receive oral upadacitinib tablets as prescribed by the physician prior to enrolling in this study in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population, and indication. The overall duration of the study is approximately 2 years. Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and questionnaires.

Condition or disease

Atopic Dermatitis

Study Type : Observational
Estimated Enrollment : 772 participants
Official Title: Non-Interventional, Prospective Observational Cohort Study to Investigate the Effectiveness and Sustained Disease Control of an Upadacitinib Therapy in Moderate to Severe Atopic Dermatitis Patients Over Two Years
Actual Study Start Date : December 13, 2021
Estimated Primary Completion Date : November 30, 2026
Estimated Study Completion Date : November 30, 2026

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 12 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Body weight >=30 kg at baseline for participants between >=12 and <18 years of age.
  • Physician confirmed diagnosis of moderate to severe atopic dermatitis at the time of enrollment.
  • Upadacitinib initiated as per the local label. The decision to prescribe upadacitinib must have been made prior to and independently of study participation.
  • Medical and medication history available at least for the last 6 months.
Exclusion Criteria
  • - Current participation in interventional research (note: this does not include non-interventional, post-marketing observational studies, or registry participation).

A Study to Assess Disease Activity in Adolescent and Adult Participants With Atopic Dermatitis Who Receive Oral Upadacitinib Tablets in a Real-World Setting

Location Details


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A Study to Assess Disease Activity in Adolescent and Adult Participants With Atopic Dermatitis Who Receive Oral Upadacitinib Tablets in a Real-World Setting

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Recruiting

Germany, Baden-Wuerttemberg

Universitaetsklinik Heidelberg /ID# 245834

Heidelberg, Baden-Wuerttemberg, Germany, 69120

Recruiting

Germany, Brandenburg

Praxis Dr. Behnke /ID# 248870

Panketal, Brandenburg, Germany, 16341

Recruiting

Germany, Brandenburg

Praxis Dr. Asadullah /ID# 243944

Potsdam, Brandenburg, Germany, 14467

Recruiting

Germany, Brandenburg

Hautärzte am Nauener Tor /ID# 261533

Potsdam, Brandenburg, Germany, 14469

Recruiting

Germany, Hessen

Universitaetsklinikum Frankfurt /ID# 241766

Frankfurt am Main, Hessen, Germany, 60590

Recruiting

Germany, Rheinland-Pfalz

CMS3 Company for Medical Study /ID# 241659

Selters, Rheinland-Pfalz, Germany, 56242

Recruiting

Germany, Saarland

HMS GmbH Zimmer /ID# 241657

Merzig, Saarland, Germany, 66663

Recruiting

Germany, Schleswig-Holstein

Praxis Dr. Mempel /ID# 241827

Elmshorn, Schleswig-Holstein, Germany, 25335

Recruiting

Germany, Schleswig-Holstein

Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 240096

Kiel, Schleswig-Holstein, Germany, 24105

Recruiting

Germany, Schleswig-Holstein

Dermatologie Moelln Praxis Dr. Bodo Segert /ID# 242280

Mölln, Schleswig-Holstein, Germany, 23879

Recruiting

Germany,

Hoeller-Obrigkeit, Aachen, DE /ID# 245430

Aachen, Germany, 52064

Recruiting

Germany,

Petri, Ahaus, DE /ID# 243452

Ahaus, Germany, 48683

Recruiting

Germany,

Dr. Stoeber /ID# 251066

Ahlen, Germany, 59227

Recruiting

Germany,

Praxis Dr. Mihaescu /ID# 241825

Augsburg, Germany, 86150

Recruiting

Germany,

Mauer, Bad Kreuznach, DE /ID# 241990

Bad Kreuznach, Germany, 55543

Recruiting

Germany,

Timmel/Timm/Vorwerk, Bergen /ID# 241661

Bergen, Germany, 18528

Recruiting

Germany,

Hautarztpraxis Dr. med. Christiane Handrick /ID# 262667

Berlin, Germany, 10117

Recruiting

Germany,

Praxis Dermatologie am Savigny /ID# 248846

Berlin, Germany, 10623

Recruiting

Germany,

Dre. Gellrich/Klein/Soost /ID# 250301

Berlin, Germany, 12247

Recruiting

Germany,

Schirmer, Berlin, DE /ID# 241684

Berlin, Germany, 12489

Recruiting

Germany,

Kors, Berlin, DE /ID# 241847

Berlin, Germany, 13086

Recruiting

Germany,

Dues/Manasterski, Berlin, DE /ID# 243885

Berlin, Germany, 13507

Recruiting

Germany,

Hautarztzentrum Tegel /ID# 241826

Berlin, Germany, 13507

Recruiting

Germany,

Haut Pur - Dermatologische Gemeinschaftspraxis /ID# 243943

Berlin, Germany, 13597

Recruiting

Germany,

Klinikum Rosenhoehe /ID# 241601

Bielefeld, Germany, 33647

Recruiting

Germany,

Praxis fuer Innere Medizin/Rheumatologie /ID# 241846

Blaubeuren, Germany, 89143

Recruiting

Germany,

Praxis T. Schadeck /ID# 241768

Bogen, Germany, 94327

Recruiting

Germany,

Barth, Borna, DE /ID# 248871

Borna, Germany, 04552

Recruiting

Germany,

Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 241658

Bramsche, Germany, 49565

Recruiting

Germany,

Schwichtenberg, Bremen, DE /ID# 241683

Bremen, Germany, 28779

Recruiting

Germany,

Praxis P. Hausler-Mehlhorn /ID# 241527

Chemnitz, Germany, 09130

Recruiting

Germany,

Dr. Hoffmann /ID# 245423

Cologne, Germany, 50674

Recruiting

Germany,

Derma Köln /ID# 241856

Cologne, Germany, 50737

Recruiting

Germany,

Praxis Dr. Sbornik /ID# 241818

Deggendorf, Germany, 94469

Recruiting

Germany,

Hautmedizin Delitzsch /ID# 251394

Delitzsch, Germany, 04509

Recruiting

Germany,

Richter-Huhn, Dresden, DE /ID# 241822

Dresden, Germany, 01219

Recruiting

Germany,

Praxis Dr. Korge /ID# 241531

Dueren, Germany, 52349

Recruiting

Germany,

Praxis Dres. Freitag/Knoell /ID# 242278

Falkensee, Germany, 14612

Recruiting

Germany,

Praxis Dr. Hong-Weldemann /ID# 248844

Freiburg im Breisgau, Germany, 79098

Recruiting

Germany,

Kurzen, Freising, DE /ID# 241845

Freising, Germany, 85354

Recruiting

Germany,

Hautarztpraxis Friedberg Dr. med. Wilfried Jungkunz /ID# 248851

Friedberg (Hessen), Germany, 61169

Recruiting

Germany,

Rotterdam, Gelsenkirchen, DE /ID# 241819

Gelsenkirchen, Germany, 45897

Recruiting

Germany,

Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 241821

Gelsenkirchen, Germany, 45899

Recruiting

Germany,

Praxis Dr. Lange /ID# 241829

Gera, Germany, 07548

Recruiting

Germany,

Loth, Gernsbach, DE /ID# 241828

Gernsbach, Germany, 76593

Recruiting

Germany,

Hautarztpraxis Dr. Budihardja /ID# 241851

Gießen, Germany, 35392

Recruiting

Germany,

Brinkmann & Partner, Gladbeck, /ID# 241850

Gladbeck, Germany, 45964

Recruiting

Germany,

Dr. Krueger /ID# 265150

Goslar, Germany, 38640

Recruiting

Germany,

Herrmann, Greifswald, DE /ID# 241889

Greifswald, Germany, 17489

Recruiting

Germany,

Grossmann, Grossenhain, DE /ID# 250303

Grossenhain, Germany, 01558

Recruiting

Germany,

Praxis Dr. Wegener /ID# 263731

Hamburg, Germany, 20095

Recruiting

Germany,

Cutaneum /ID# 249104

Hamburg, Germany, 20249

Recruiting

Germany,

Dermatologikum Hamburg GmbH /ID# 245431

Hamburg, Germany, 20354

Recruiting

Germany,

Hautarztpraxis Luetten/Sack /ID# 241534

Hamburg, Germany, 21109

Recruiting

Germany,

Praxis Dr. Kasche /ID# 249102

Hamburg, Germany, 22549

Recruiting

Germany,

MVZ Prof. Dr. Ockenfels Haut- und Allergie-Praxisklinik GmbH /ID# 245395

Hanau, Germany, 63450

Recruiting

Germany,

Praxis Dres. Kaspari /Schenck /ID# 241688

Hannover, Germany, 30159

Recruiting

Germany,

Dr. Buerkle /ID# 250299

Haslach im Kinzigtal, Germany, 77716

Recruiting

Germany,

Hautarztpraxis Haßberge /ID# 257648

Haßfurt, Germany, 97437

Recruiting

Germany,

Durani & Durani, Heidelberg,DE /ID# 249172

Heidelberg, Germany, 69115

Recruiting

Germany,

Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 241908

Heilbad Heiligenstadt, Germany, 37308

Recruiting

Germany,

Haut- u. Laserzentrum Heilbronn /ID# 250305

Heilbronn, Germany, 74072

Recruiting

Germany,

Hausarztpraxis & Laserzentrum Dr. Zimmermann & Kollegen /ID# 251051

Heusenstamm, Germany, 63150

Recruiting

Germany,

Praxis Dres. Bischoff/Danz /ID# 241852

Ilmenau, Germany, 98693

Recruiting

Germany,

Stockmeier, Ingoldstadt, DE /ID# 248877

Ingolstadt, Germany, 85049

Recruiting

Germany,

Hautarztpraxis Weidgang /ID# 248850

Juelich, Germany, 52428

Recruiting

Germany,

Derma Sana /ID# 241854

Karlsruhe, Germany, 76133

Recruiting

Germany,

Dermatologische Praxis Kempen /ID# 248852

Kempen, Germany, 47906

Recruiting

Germany,

Grossmann, Koblenz, DE /ID# 242992

Koblenz, Germany, 56068

Recruiting

Germany,

Praxis Dres. Bornemann/Reinerth /ID# 257649

Krefeld, Germany, 47798

Recruiting

Germany,

Dres. Jacobs & Kollegen /ID# 241989

Kulmbach, Germany, 95326

Recruiting

Germany,

Hautarztpraxis Langenau /ID# 242279

Langenau, Germany, 89129

Recruiting

Germany,

Neubauer, Leipzig, DE /ID# 241823

Leipzig, Germany, 04209

Recruiting

Germany,

Praxis Dres. Wiemers/Wiemers /ID# 241602

Leipzig, Germany, 04317

Recruiting

Germany,

Haut- und Allergie-Zentrum Lippstadt /ID# 241929

Lippstadt, Germany, 59557

Completed

Germany,

Hagemeier, Loehne, DE /ID# 241886

Loehne, Germany, 32584

Recruiting

Germany,

Magdeburger Company for Medical Studies & Services GmbH /ID# 248849

Magdeburg, Germany, 39104

Recruiting

Germany,

MVZ "Im Altstadtquartier" Magdeburg /ID# 261366

Magdeburg, Germany, 39104

Recruiting

Germany,

Praxis Dr. Raschke /ID# 251398

Magdeburg, Germany, 39104

Recruiting

Germany,

Universitaetsklinikum Magdeburg /ID# 249174

Magdeburg, Germany, 39120

Recruiting

Germany,

Hausärzte am Fastnachtsbrunnen /ID# 250304

Mainz, Germany, 55116

Recruiting

Germany,

Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 243325

Mainz, Germany, 55128

Recruiting

Germany,

Beldio Research GmbH /ID# 245830

Memmingen, Germany, 87700

Recruiting

Germany,

Hautzentrum am Marienplatz /ID# 248847

Munich, Germany, 80331

Recruiting

Germany,

Quack, Munich, DE /ID# 241536

Munich, Germany, 81539

Recruiting

Germany,

Dr. Gißler-Walter /ID# 248876

Mutterstadt, Germany, 67112

Recruiting

Germany,

ZENTderma /ID# 241539

Mönchengladbach, Germany, 41061

Recruiting

Germany,

Dr. Rezai /ID# 250298

Münster, Germany, 48143

Recruiting

Germany,

Dermatologie im Apfelgarten /ID# 263704

Neu Wulmstorf, Germany, 21629

Recruiting

Germany,

Praxis Dr. Konstantin Ertner /ID# 249153

Nuremberg, Germany, 90402

Recruiting

Germany,

Voelkel, Nuremberg, DE /ID# 252445

Nuremberg, Germany, 90419

Recruiting

Germany,

MediCorium Zentrum fuer Dermatologie und Aesthetik /ID# 243328

Oberursel, Germany, 61440

Recruiting

Germany,

Hockmann, Oelde, DE /ID# 241906

Oelde, Germany, 59302

Recruiting

Germany,

Harzklinikum Dorothea Christiane Erxleben /ID# 251067

Quedlinburg, Germany, 06484

Recruiting

Germany,

Kramer/Mortazawi, Remscheid /ID# 241824

Remscheid, Germany, 42897

Recruiting

Germany,

Dr. Schaefers /ID# 255492

Reutlingen, Germany, 72764

Recruiting

Germany,

Praxis Dr. Fränken /ID# 241853

Schwelm, Germany, 58332

Recruiting

Germany,

Haut- und Laserzentrum Hunsrück /ID# 243882

Simmern, Germany, 55469

Recruiting

Germany,

Karl, Soest, DE /ID# 241909

Soest, Germany, 59494

Completed

Germany,

Gemeinschaftspraxis fur Dermatologie /ID# 245831

Stadtroda, Germany, 07646

Active, not recruiting

Germany,

Praxis Dr. Termeer /ID# 241662

Stuttgart, Germany, 70499

Recruiting

Germany,

Flegl MD Stuttgart Germany /ID# 250302

Stuttgart, Germany, 70567

Recruiting

Germany,

Jasnoch/Kock/Borrosch, Vechta, /ID# 252081

Vechta, Germany, 49377

Recruiting

Germany,

Barnikol, Waltershausen, DE /ID# 241844

Waltershausen, Germany, 99880

Recruiting

Germany,

Praxis Dehmel / Brand-Opitzer /ID# 243884

Wasserburg A. Inn, Germany, 83512

Recruiting

Germany,

Dr. Barbara Kempkes, Werne /ID# 241910

Werne, Germany, 59368

Recruiting

Germany,

Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 241907

Witten, Germany, 58453

Recruiting

Germany,

Albrecht, Wurzen, DE /ID# 241988

Wurzen, Germany, 04808

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