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NCT05139784 | Recruiting | Type 1 Diabetes


BeAT1D: Benign Autoimmunity and Type 1 Diabetes
Sponsor:

National Institute of Health and Medical Research, France

Brief Summary:

National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.

Condition or disease

Type 1 Diabetes

Intervention/treatment

Biosampling

Detailed Description:

The overall objective of this study is to define the differential characteristics of autoimmune T and B lymphocytes across individuals with T1D, other forms of diabetes or autoimmunity, and no disease. The hypothesis is that the characterization of the autoimmune T and B lymphocytes involved in T1D development may allow us to clarify the pathophysiological mechanisms of disease and to identify novel biomarkers for diagnostic, prognostic and therapeutic follow-up applications.}}

Study Type : Observational
Estimated Enrollment : 740 participants
Official Title : BeAT1D: Benign Autoimmunity and Type 1 Diabetes
Actual Study Start Date : October 24, 2022
Estimated Primary Completion Date : December 2027
Estimated Study Completion Date : December 2027

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 1 Year
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Criteria
Inclusion Criteria
  • Type 1 diabetes: type 1 diabetes, as defined by hyperglycemia and long-term insulin therapy started within 6 months from clinical onset; and/or the presence of at least one anti-islet auto-antibody.
  • Other forms of diabetes or autoimmune endocrinopathy: other forms of diabetes (e.g. type 2, ketosis-prone, familial, secondary, immunotherapy-induced diabetes); and/or other autoimmune endocrinopathies, isolated or multiple.
  • No diabetes: absence of diabetes or impaired glucose tolerance; absence of tumor, infectious or immune pathologies, or other conditions related to autoimmune or metabolic alterations that may bias the variables under study.
  • Lymphadenectomy planned in the frame of an abdominal surgery: pancreatic lymphadenectomy planned at the occasion of an abdominal surgery for the treatment of an underlying condition.
Exclusion Criteria
  • For all participants: ongoing pregnancy; known HIV/HCV infection; absence of social security coverage; placement under judicial protection; absence of signature of the informed study consent.

BeAT1D: Benign Autoimmunity and Type 1 Diabetes

Location Details


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BeAT1D: Benign Autoimmunity and Type 1 Diabetes

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Not yet recruiting

France, Ile-de-France

APHP Avicenna Hospital

Bobigny, Ile-de-France, France, 93000

Not yet recruiting

France, Ile-de-France

APHP Hôpital J. Verdier

Bondy, Ile-de-France, France, 93140

Not yet recruiting

France, Ile-de-France

APHP L. Mourier Hospital

Doves, Ile-de-France, France, 92700

Not yet recruiting

France, Ile-de-France

South Francilien Hospital

Corbeil-Essonnes, Ile-de-France, France, 91100

Not yet recruiting

France, Ile-de-France

Mignot Hospital - Pediatric Department

Le Chesnay, Ile-de-France, France, 78150

Not yet recruiting

France, Ile-de-France

Mignot Hospital - Adult Diabetology/Endocrinology Services

Le Chesnay, Ile-de-France, France, 78150

Not yet recruiting

France, Ile-de-France

APHP Kremlin-Bicêtre Hospital

The Kremlin-Bicêtre, Ile-de-France, France, 94270

Not yet recruiting

France, Ile-de-France

APHP Lariboisière Hospital

Paris, Ile-de-France, France, 75010

Not yet recruiting

France, Ile-de-France

APHP Saint Antoine Hospital

Paris, Ile-de-France, France, 75012

Not yet recruiting

France, Ile-de-France

APHP Pitié-Salpêtrière Hospital - Surgery Department

Paris, Ile-de-France, France, 75013

Not yet recruiting

France, Ile-de-France

Pitié-Salpêtrière Hospital - Diabetology Department

Paris, Ile-de-France, France, 75013

Not yet recruiting

France, Ile-de-France

APHP Cochin Hospital - Surgery Department

Paris, Ile-de-France, France, 75014

Recruiting

France, Ile-de-France

APHP Cochin Hospital - Department of Diabetology and Clinical Immunology

Paris, Ile-de-France, France, 75014

Not yet recruiting

France, Ile-de-France

APHP European Hospital G. Pompidou

Paris, Ile-de-France, France, 75015

Not yet recruiting

France, Ile-de-France

APHP Bichat Hospital

Paris, Ile-de-France, France, 75018

Not yet recruiting

France, Ile-de-France

APHP R. Debré Hospital

Paris, Ile-de-France, France, 75019

Not yet recruiting

France, Ile-de-France

René Dubos Hospital

Pontoise, Ile-de-France, France, 95300

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