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NCT05135078 | Not yet recruiting | Hematologic Diseases


Monitoring Risks for Hematological Changes in Gas Station Workers
Sponsor:

Sohag University

Information provided by (Responsible Party):

Sara Talaat Taha

Brief Summary:

Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma. Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression.

Condition or disease

Hematologic Diseases

Detailed Description:

Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma. It is known that severe bone marrow dysplasia is frequently accompanied by early alterations in the immune system and in peripheral cell subsets. The bone marrow injury by benzene metabolites is a strong predisposing factor in the pathogenesis of Benzene-induced hematopoietic disease .Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression. The reactive metabolite of benzene, 1,4-benzoquinone (BQ) is suggested to be a key molecule of benzene-induced hematotoxicity and carcinogenicity as it cause abnormal accumulation of myeloid cells and precursors, which cause benzene induced cytopenia and myeloid dysplasia in humans.

Study Type : Observational
Estimated Enrollment : 50 participants
Official Title: Monitoring Risks for Hematological Changes in Gas Station Workers
Actual Study Start Date : December 1, 2021
Estimated Primary Completion Date : December 1, 2022
Estimated Study Completion Date : December 1, 2022

Information not available for Arms and Intervention/treatment

Ages Eligible for Study:
Sexes Eligible for Study: Male
Criteria
Inclusion Criteria
  • This study will be conducted on a group of gas station workers exposed to benzene for more than 3 years .
Exclusion Criteria
  • diagnosed gas station workers with blood malignancies .
  • gas station workers exposed to benzene for less than 3 years .

Monitoring Risks for Hematological Changes in Gas Station Workers

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Monitoring Risks for Hematological Changes in Gas Station Workers

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