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NCT05134779 | Recruiting | Breast Cancer


De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You
Sponsor:

Weill Medical College of Cornell University

Brief Summary:

This is a live biobank study for breast cancer (BC) patients where samples will be collected at inflection points in the course of the disease.

Condition or disease

Breast Cancer

Intervention/treatment

Live Biobank

Detailed Description:

To test this hypothesis the investigators will focus on studying BC patients using an innovative approach, the DIGNITY Study (De-convoluting interactions between genes, the cancer environment, and the immune system to develop therapies that work for you) designed to building a live tissue biobank of Patient Derived Tumor Organoids (PDOs) derived from tumor at surgery, preceded or not by neoadjuvant therapy (NAT), and at recurrence/metastasis. BC patients enrolled in this study are consented to enable investigators to generate a biobank of tumor tissue (obtained from surgically removed excess that would otherwise be disposed off ) and matched blood cells ( obtained from an already existing line or a venipuncture ordered per standard of care testing) at key timepoints in their treatment course.}}

Study Type : Observational
Estimated Enrollment : 400 participants
Official Title : De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You
Actual Study Start Date : January 12, 2022
Estimated Primary Completion Date : December 31, 2027
Estimated Study Completion Date : December 31, 2028

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 90 Years
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • All patients will historically proven BC are eligible to be on the study
Exclusion Criteria
  • Carriers of other cancers other than breast.

De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You

Location Details


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De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations


Recruiting

United States, New York

Brooklyn Methodist Hospital - NewYork Presbyterian

New York, New York, United States, 11215

Recruiting

United States, New York

New York Presbyterian Hospital - Queens

New York, New York, United States, 11355

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