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NCT05132751 | Not yet recruiting | Mechanical Ventilation


Machine Learning Ventilator Decision System VS. Standard Controlled Ventilation
Sponsor:

Hu Anmin

Information provided by (Responsible Party):

Hu Anmin

Brief Summary:

Ventilator-induced lung injury is associated with increased morbidity and mortality. Despite intense efforts in basic and clinical research, an individualized ventilation strategy for critically ill patients remains a major challenge. However, an individualized mechanical ventilation approach remains a challenging task: A multitude of factors, e.g., lab values, vitals, comorbidities, disease progression, and other clinical data must be taken into consideration when choosing a patient's specific optimal ventilation regime. The aim of this work was to evaluate the machine learning ventilator decision system, which is able to suggest a dynamically optimized mechanical ventilation regime for critically-ill patients. Compare with standard controlled ventilation, to test whether the clinical application of the machine learning ventilator decision system reduces mechanical ventilation time and mortality.

Condition or disease

Mechanical Ventilation

Critically Ill Patients

Intervention/treatment

Machine Learning Ventilator Decision System

Phase

Not Applicable

Study Type : Interventional
Estimated Enrollment : 300 participants
Masking: Triple
Primary Purpose: Treatment
Official Title: Effect of a Machine Learning Ventilator Decision System Versus Standard Controlled Ventilation on in Critical Care: a Randomized Trial
Actual Study Start Date : January 1, 2022
Estimated Primary Completion Date : January 1, 2022
Estimated Study Completion Date : December 1, 2024
Arm Intervention/treatment

Experimental: Group A

Machine Learning Ventilator Decision System Ventilation

Device: Machine Learning Ventilator Decision System

Active Comparator: Group B

Standard Controlled Ventilation

Device: Machine Learning Ventilator Decision System

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • only the first ICU stay was eligible;
  • adults ≥ 18 years of age on ICU admission;
  • estimate mechanical ventilation time ≥24 hours;

Machine Learning Ventilator Decision System VS. Standard Controlled Ventilation

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Machine Learning Ventilator Decision System VS. Standard Controlled Ventilation

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