Complutense University of Madrid
Jesus Torres Garcia Denche
Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration. The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (ibuprofen) affects on postoperative pain, swelling and open mouth limitation comparing to the normal dosage.
Tooth, Impacted
Trismus
Pain
Inflammatory Response
Ibuprofen 400 mg
Ibuprofen 400 mg
Not Applicable
A randomized crossover split-mouth clinical trial will be performed. After third molar extractions, patients will be prescribed ramdomly in one side wit the normal medication dosage while the contralateral side will be prescribed a modified dosage. Moreover, a blood sample will be obtained to analize the inflammatory profile.}}
| Study Type : | Interventional |
| Estimated Enrollment : | 10 participants |
| Masking : | Double |
| Primary Purpose : | Treatment |
| Official Title : | Efficacy of the Dosage of a Non-steroidal Anti-inflammatory (Ibuprofen) on Inflammation and Postoperative Pain After Lower Third Molar Surgery. |
| Actual Study Start Date : | December 10, 2021 |
| Estimated Primary Completion Date : | December 10, 2021 |
| Estimated Study Completion Date : | February 2, 2022 |
| Arm | Intervention/treatment |
|---|---|
|
Experimental: Modified dosage Ibuprofen pill at morning and afternoon; Placebo at night |
Drug: Ibuprofen 400 mg |
|
Active Comparator: Normal dosage Ibuprofen three times a day: morning, afternoon and night |
Drug: Ibuprofen 400 mg |
| Ages Eligible for Study: | 18 Years to 35 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Fabian Perez Gonzalez
Madrid, Spain, 28040