Scentech Medical Technologies Ltd
The objective of this study will be to evaluate the effect of vaccination on breath VOC content. By capturing and analyzing the breath of anti-COVID-19 vaccinated subjects during the period of antibody production, the investigators will determine and quantify all the compounds associated with the body reaction to the COVID-19 antigen.
Covid19
vaccination against COVID 19
Not Applicable
The objective of this study will be to evaluate the effect of vaccination on breath VOC content. By capturing and analyzing the breath of anti-COVID-19 vaccinated subjects during the period of antibody production, the investigators will determine and quantify all the compounds associated with the body reaction to the COVID-19 antigen. Rapidly growing serological evidence shows that IgM, IgG, and IgA antibodies against the S or N proteins evolve rapidly in the serum of asymptomatic as well as symptomatic COVID-19 patients within a week of infection or symptom onset and stay elevated with progressing disease. Since the standard serology testing at Shamir Medical center tracks the presence of IgG only, those serologic tests will be conducted before and 48 hours following the second vaccination dose. Nevertheless, since IgM antibodies are known to be produced by four to seven days following the first dose of vaccination, although IgM serology testing cannot be performed, the investigators are interested in sampling breath at this time range, in order for them to correlate it with the changes in the subjects' physiologic condition. Since this is an unknown metabolic volatile compound mixture, the goal will be to identify compounds and quantify them with a high level of precision and subsequently correlate them with the disease.}}
Study Type : | Interventional |
Estimated Enrollment : | 43 participants |
Masking : | None (Open Label) |
Primary Purpose : | Diagnostic |
Official Title : | Evaluation of Anti-COVID 19 Pfizer Vaccination Effect on COVID 19 Detection Using Breath Analysis |
Actual Study Start Date : | December 24, 2020 |
Estimated Primary Completion Date : | December 24, 2021 |
Estimated Study Completion Date : | December 24, 2021 |
Arm | Intervention/treatment |
---|---|
No Intervention: Healthy Volunteers that are not to be vaccinated against COVID 19 Healthy Volunteers that are not eligible to be vaccinated against COVID 19 |
|
Experimental: Healthy Volunteers that are assigned to be vaccinated against COVID 19 Healthy Volunteers that are eligible to be vaccinated against COVID 19 |
Ages Eligible for Study: | 18 Years to 75 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Shamir Medical Center
Bir Yaqif, Israel,