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NCT04766294 | Completed | COVID-19

Macrophage Activation Markers in COVID-19 Patients

Sohag University

Information provided by (Responsible Party):

Nahed Fathallah Fahmy

Brief Summary:

This study is aiming to find the relation between the severity of COVID-19 in diabetic and obese patients and the high serum levels of matrix metalloproteinase-7 (MMP-7),matrix metalloproteinase-9 (MMP-9), TGF-β and PDGF Macrophage Activation Markers

Condition or disease


Detailed Description:

Acute respiratory distress syndrome (ARDS) commonly occurs in COVID-19 patients who are diabetic and obese, ARDS is characterized by inflammation and pulmonary fibrosis mediated by cytokines and biomarkers released from activated alveolar macrophages, also cytokine storm may occurs leading to multiple organ failure. These sequelae of COVID-19 disease in obese and diabetic patients are attributed to elevated plasma lipopolysaccharide which is the main activator of M1 and M2 macrophages. chronic activation of macrophages leads to production of profibrotic markers as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), matrix metalloproteinase-7 (MMP7) and matrix metalloproteinase-9 (MMP9) which promote fibrogenesis. In this research, we measure circulatory alveolar macrophage activation markers in COVID-19 obese patients with type 1 and type 2 diabetes.

Study Type : Observational
Estimated Enrollment : 70 participants
Official Title: Is the Severity of COVID-19 in Obese and Diabetic Patients Linked to High Serum Levels of MMP-7, MMP-9, TGF-β and PDGF Macrophage Activation Markers?
Actual Study Start Date : April 25, 2020
Estimated Primary Completion Date : March 15, 2021
Estimated Study Completion Date : April 1, 2021

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 19 Years to 70 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria
  • Overweight patients with body mass index higher than 25 and obese patients with body mass index higher than 30 were selected to be included
  • Type one and type two diabetes mellitus patients were also included
Exclusion Criteria
  • -

Macrophage Activation Markers in COVID-19 Patients

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Macrophage Activation Markers in COVID-19 Patients

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Faculty of medicine - sohag university

Sohag, Egypt, 82524