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NCT04353310 | Withdrawn | Asthma

Evaluating Effects of Curcumin in Moderate to Severe Asthmatics
Sponsor:

Loma Linda University

Brief Summary:

The purpose of this investigator-initiated study is to evaluate the effects of oral curcumin supplementation versus placebo in adult patients with moderate to severe asthma. Curcumin, a derivative of turmeric, has been shown in animal models to inhibit the secretion of pro-inflammatory cytokines and decrease airway constriction and hyperreactivity with only a few observational studies available in humans with discordant results.

Condition or disease

Asthma

Intervention/treatment

Curcumin

Placebo

Phase

Phase 2

Study Type : Interventional
Estimated Enrollment : 0 participants
Masking : Triple
Primary Purpose : Prevention
Official Title : Evaluating the Effects of Curcumin in Moderate to Severe Asthmatics
Actual Study Start Date : September 2021
Estimated Primary Completion Date : November 9, 2021
Estimated Study Completion Date : November 9, 2021
Arm Intervention/treatment

Experimental: Curcumin

Drug: Curcumin

Placebo Comparator: Placebo

Other: Placebo
Ages Eligible for Study: 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria
Inclusion Criteria
  • Provision of signed and dated informed consent form
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Male or female, aged 18 and older
  • Physician diagnosed moderate to severe asthma: (GINA 2018)
  • a. Stable asthma that requires ICS/LABA and/or an additional controller agent (i.e. LTRA, LAMA)
  • Ability to take oral medication and be willing to adhere to the regimen
  • Ability to speak and read English
  • If female and sexually active, should use effective forms of birth control
Exclusion Criteria
  • Current use of turmeric (curcumin) or use within the last 7 days
  • Current use of biologic therapy/ immunotherapy/ or bronchothermoplasty
  • Pregnancy or lactation
  • Known allergic reactions to components of turmeric (curcumin)
  • Current use of anticoagulants, and history of coagulopathy or liver disease
  • INR greater than 2.0, PTT greater than 45.0 seconds
Evaluating Effects of Curcumin in Moderate to Severe Asthmatics

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Evaluating Effects of Curcumin in Moderate to Severe Asthmatics

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